Detailed information NTG0503541

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI21_RS08265
• Genome accession: NZ_CP064609
• Coordinates: 1666037..1667083 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG348
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1661037..1672083

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI21_RS08235 (HWI21_08160)	-	1661421..1662662 (-)	1242	WP_001832467.1	aminopeptidase	-
HWI21_RS08240 (HWI21_08165)	-	1662664..1662879 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI21_RS08245 (HWI21_08170)	-	1663020..1663484 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI21_RS08250 (HWI21_08175)	-	1663492..1663776 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI21_RS08255 (HWI21_08180)	-	1664183..1665361 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI21_RS08260 (HWI21_08185)	vraR	1665418..1666047 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI21_RS08265 (HWI21_08190)	vraS	1666037..1667083 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI21_RS08270 (HWI21_08195)	liaF	1667080..1667781 (-)	702	WP_063964223.1	cell wall-active antibiotics response protein LiaF	-
HWI21_RS08275 (HWI21_08200)	-	1667796..1668182 (-)	387	WP_001830382.1	hypothetical protein	-
HWI21_RS08280 (HWI21_08205)	map	1668340..1669095 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI21_RS08285 (HWI21_08210)	-	1669269..1670255 (+)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI21_RS08290 (HWI21_08215)	isaB	1670406..1670942 (-)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=503541 HWI21_RS08265 WP_001830374.1 1666037..1667083(-) (vraS) [Staphylococcus epidermidis strain UMCG348]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=503541 HWI21_RS08265 WP_001830374.1 1666037..1667083(-) (vraS) [Staphylococcus epidermidis strain UMCG348]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92