Detailed information NTG0503503

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI22_RS08325
• Genome accession: NZ_CP064606
• Coordinates: 1670332..1671378 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG349
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1665332..1676378

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI22_RS08295 (HWI22_08205)	-	1665716..1666957 (-)	1242	WP_001832467.1	aminopeptidase	-
HWI22_RS08300 (HWI22_08210)	-	1666959..1667174 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI22_RS08305 (HWI22_08215)	-	1667315..1667779 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI22_RS08310 (HWI22_08220)	-	1667787..1668071 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI22_RS08315 (HWI22_08225)	-	1668478..1669656 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI22_RS08320 (HWI22_08230)	vraR	1669713..1670342 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI22_RS08325 (HWI22_08235)	vraS	1670332..1671378 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI22_RS08330 (HWI22_08240)	liaF	1671375..1672076 (-)	702	WP_063964223.1	cell wall-active antibiotics response protein LiaF	-
HWI22_RS08335 (HWI22_08245)	-	1672091..1672477 (-)	387	WP_001830382.1	hypothetical protein	-
HWI22_RS08340 (HWI22_08250)	map	1672635..1673390 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI22_RS08345 (HWI22_08255)	-	1673564..1674550 (+)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI22_RS08350 (HWI22_08260)	isaB	1674701..1675237 (-)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=503503 HWI22_RS08325 WP_001830374.1 1670332..1671378(-) (vraS) [Staphylococcus epidermidis strain UMCG349]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=503503 HWI22_RS08325 WP_001830374.1 1670332..1671378(-) (vraS) [Staphylococcus epidermidis strain UMCG349]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92