Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | HWI23_RS13505 | Genome accession | NZ_CP064603 |
| Coordinates | 2734154..2735782 (+) | Length | 542 a.a. |
| NCBI ID | WP_001186596.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain UMCG350 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2697649..2753945 | 2734154..2735782 | within | 0 |
Gene organization within MGE regions
Location: 2697649..2753945
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI23_RS13315 (HWI23_13180) | - | 2697649..2698461 (-) | 813 | WP_002504699.1 | abortive infection system antitoxin AbiGi family protein | - |
| HWI23_RS13320 (HWI23_13185) | - | 2698652..2700166 (+) | 1515 | WP_002504700.1 | class I SAM-dependent DNA methyltransferase | - |
| HWI23_RS13325 (HWI23_13190) | - | 2700156..2701430 (+) | 1275 | WP_002504701.1 | restriction endonuclease subunit S | - |
| HWI23_RS13330 (HWI23_13195) | - | 2701414..2704533 (+) | 3120 | WP_002504702.1 | type I restriction endonuclease subunit R | - |
| HWI23_RS13335 (HWI23_13200) | - | 2704611..2704934 (-) | 324 | WP_001176049.1 | PepSY domain-containing protein | - |
| HWI23_RS13340 (HWI23_13205) | - | 2705328..2705549 (-) | 222 | WP_002504703.1 | hypothetical protein | - |
| HWI23_RS13345 (HWI23_13210) | - | 2705498..2705941 (-) | 444 | WP_000941333.1 | hypothetical protein | - |
| HWI23_RS13350 (HWI23_13215) | - | 2706003..2706530 (-) | 528 | WP_002504704.1 | hypothetical protein | - |
| HWI23_RS13355 (HWI23_13220) | - | 2706665..2707153 (-) | 489 | WP_000393586.1 | hypothetical protein | - |
| HWI23_RS13360 (HWI23_13225) | - | 2707169..2707459 (-) | 291 | WP_000065261.1 | hypothetical protein | - |
| HWI23_RS13365 (HWI23_13230) | - | 2707516..2708388 (-) | 873 | WP_000373149.1 | HTH domain-containing protein | - |
| HWI23_RS13370 (HWI23_13235) | - | 2708558..2709004 (-) | 447 | WP_002504705.1 | RadC family protein | - |
| HWI23_RS13375 (HWI23_13240) | - | 2709025..2709531 (-) | 507 | WP_000849085.1 | DUF1643 domain-containing protein | - |
| HWI23_RS13380 (HWI23_13245) | - | 2709547..2709858 (-) | 312 | WP_001083108.1 | DUF960 family protein | - |
| HWI23_RS13385 (HWI23_13250) | - | 2709954..2710292 (-) | 339 | WP_063964250.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI23_RS13390 (HWI23_13255) | ccrC | 2710398..2712074 (-) | 1677 | WP_002504707.1 | cassette chromosome recombinase CcrC | - |
| HWI23_RS13395 (HWI23_13260) | - | 2712299..2713942 (-) | 1644 | WP_002504708.1 | DUF5906 domain-containing protein | - |
| HWI23_RS13400 (HWI23_13265) | - | 2713939..2714310 (-) | 372 | WP_002437511.1 | hypothetical protein | - |
| HWI23_RS13405 (HWI23_13270) | - | 2714303..2715412 (-) | 1110 | WP_002437509.1 | DNA polymerase | - |
| HWI23_RS13410 (HWI23_13275) | - | 2715582..2717594 (-) | 2013 | WP_012088687.1 | hypothetical protein | - |
| HWI23_RS13415 (HWI23_13280) | - | 2717756..2718685 (-) | 930 | WP_002504713.1 | YafY family protein | - |
| HWI23_RS13420 (HWI23_13285) | - | 2718766..2719194 (+) | 429 | WP_000671997.1 | VOC family protein | - |
| HWI23_RS13425 (HWI23_13290) | - | 2719254..2719928 (-) | 675 | Protein_2603 | IS6 family transposase | - |
| HWI23_RS13430 (HWI23_13295) | - | 2720139..2721329 (+) | 1191 | WP_000716034.1 | YbfB/YjiJ family MFS transporter | - |
| HWI23_RS13435 (HWI23_13300) | - | 2721316..2722182 (+) | 867 | WP_002504710.1 | LysR family transcriptional regulator | - |
| HWI23_RS13440 (HWI23_13305) | - | 2722195..2723265 (+) | 1071 | WP_001054882.1 | nitronate monooxygenase family protein | - |
| HWI23_RS13445 (HWI23_13310) | - | 2723430..2723789 (+) | 360 | WP_000432280.1 | DUF4870 domain-containing protein | - |
| HWI23_RS13450 (HWI23_13315) | - | 2724283..2725455 (-) | 1173 | WP_000195429.1 | IS256-like element IS256 family transposase | - |
| HWI23_RS13455 (HWI23_13320) | - | 2725533..2726132 (-) | 600 | WP_408022871.1 | hypothetical protein | - |
| HWI23_RS13460 (HWI23_13325) | - | 2726449..2726613 (-) | 165 | WP_001028954.1 | hypothetical protein | - |
| HWI23_RS13465 (HWI23_13330) | - | 2726818..2727651 (-) | 834 | WP_000694291.1 | CPBP family intramembrane glutamic endopeptidase | - |
| HWI23_RS13470 (HWI23_13335) | - | 2727688..2728014 (-) | 327 | WP_000624048.1 | helix-turn-helix domain-containing protein | - |
| HWI23_RS13475 (HWI23_13340) | - | 2728346..2728918 (-) | 573 | WP_000489177.1 | ADP-ribosyltransferase | - |
| HWI23_RS13480 (HWI23_13345) | - | 2728971..2730020 (-) | 1050 | WP_000613217.1 | hypothetical protein | - |
| HWI23_RS13485 (HWI23_13350) | ssb | 2730158..2730442 (+) | 285 | WP_000659554.1 | cassette chromosome ssDNA-binding protein | - |
| HWI23_RS13490 (HWI23_13355) | cch1 | 2730442..2732229 (+) | 1788 | WP_000181743.1 | cassette chromosome replicative helicase | - |
| HWI23_RS13495 (HWI23_13360) | - | 2732319..2732594 (+) | 276 | WP_001791132.1 | hypothetical protein | - |
| HWI23_RS13500 (HWI23_13365) | ccrA | 2732787..2734133 (+) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
| HWI23_RS13505 (HWI23_13370) | ccrB | 2734154..2735782 (+) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| HWI23_RS13510 (HWI23_13375) | - | 2736253..2736603 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI23_RS13515 (HWI23_13380) | - | 2736688..2736999 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| HWI23_RS13520 (HWI23_13385) | - | 2737018..2737539 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| HWI23_RS13525 (HWI23_13390) | - | 2737541..2737747 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| HWI23_RS13530 (HWI23_13395) | - | 2737740..2738063 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| HWI23_RS13535 (HWI23_13400) | - | 2738258..2740150 (+) | 1893 | WP_063964251.1 | site-specific integrase | - |
| HWI23_RS13540 (HWI23_13405) | - | 2740157..2740534 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| HWI23_RS13545 (HWI23_13410) | - | 2740772..2741137 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| HWI23_RS13550 (HWI23_13415) | - | 2741130..2743544 (+) | 2415 | WP_408020818.1 | heavy metal translocating P-type ATPase | - |
| HWI23_RS13555 (HWI23_13420) | - | 2743625..2744241 (+) | 617 | Protein_2629 | CadD family cadmium resistance transporter | - |
| HWI23_RS13560 (HWI23_13430) | - | 2744515..2745153 (-) | 639 | Protein_2630 | sulfite exporter TauE/SafE family protein | - |
| HWI23_RS13565 (HWI23_13435) | cstR | 2745153..2745413 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| HWI23_RS13570 (HWI23_13440) | - | 2745549..2746613 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| HWI23_RS13575 (HWI23_13445) | cstB | 2746646..2747980 (+) | 1335 | Protein_2633 | persulfide dioxygenase-sulfurtransferase CstB | - |
| HWI23_RS13580 (HWI23_13450) | - | 2748094..2749224 (-) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| HWI23_RS13585 (HWI23_13455) | psm-mec | 2749558..2749626 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| HWI23_RS13590 (HWI23_13460) | mecI | 2749711..2750082 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| HWI23_RS13595 (HWI23_13465) | mecR1 | 2750082..2751839 (-) | 1758 | WP_002504642.1 | beta-lactam sensor/signal transducer MecR1 | - |
| HWI23_RS13600 (HWI23_13470) | mecA | 2751936..2753945 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62274.15 Da Isoelectric Point: 9.7334
>NTDB_id=503474 HWI23_RS13505 WP_001186596.1 2734154..2735782(+) (ccrB) [Staphylococcus epidermidis strain UMCG350]
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI
Nucleotide
Download Length: 1629 bp
>NTDB_id=503474 HWI23_RS13505 WP_001186596.1 2734154..2735782(+) (ccrB) [Staphylococcus epidermidis strain UMCG350]
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
86.531 |
100 |
0.865 |