Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   HWI23_RS08325 Genome accession   NZ_CP064603
Coordinates   1673515..1674144 (-) Length   209 a.a.
NCBI ID   WP_001830439.1    Uniprot ID   A0A2G7HYX3
Organism   Staphylococcus epidermidis strain UMCG350     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1668515..1679144
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HWI23_RS08295 (HWI23_08205) - 1668908..1669438 (-) 531 WP_002484890.1 acyl-CoA thioesterase -
  HWI23_RS08300 (HWI23_08210) - 1669518..1670759 (-) 1242 WP_001832467.1 aminopeptidase -
  HWI23_RS08305 (HWI23_08215) - 1670761..1670976 (-) 216 WP_001830421.1 DUF1128 domain-containing protein -
  HWI23_RS08310 (HWI23_08220) - 1671117..1671581 (+) 465 WP_001830437.1 low molecular weight protein-tyrosine-phosphatase -
  HWI23_RS08315 (HWI23_08225) - 1671589..1671873 (+) 285 WP_001830401.1 YtxH domain-containing protein -
  HWI23_RS08320 (HWI23_08230) - 1672280..1673458 (+) 1179 WP_001830411.1 YihY/virulence factor BrkB family protein -
  HWI23_RS08325 (HWI23_08235) vraR 1673515..1674144 (-) 630 WP_001830439.1 two-component system response regulator VraR Regulator
  HWI23_RS08330 (HWI23_08240) vraS 1674134..1675180 (-) 1047 WP_001830374.1 sensor histidine kinase Regulator
  HWI23_RS08335 (HWI23_08245) liaF 1675177..1675878 (-) 702 WP_063964223.1 cell wall-active antibiotics response protein LiaF -
  HWI23_RS08340 (HWI23_08250) - 1675893..1676279 (-) 387 WP_001830382.1 hypothetical protein -
  HWI23_RS08345 (HWI23_08255) map 1676437..1677192 (-) 756 WP_002457092.1 type I methionyl aminopeptidase -
  HWI23_RS08350 (HWI23_08260) - 1677366..1678352 (+) 987 WP_001830388.1 aromatic acid exporter family protein -
  HWI23_RS08355 (HWI23_08265) isaB 1678503..1679039 (-) 537 WP_002470337.1 immunodominant staphylococcal antigen IsaB family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23584.19 Da        Isoelectric Point: 4.7166

>NTDB_id=503464 HWI23_RS08325 WP_001830439.1 1673515..1674144(-) (vraR) [Staphylococcus epidermidis strain UMCG350]
MAIKVLFVDDHEMVRIGISSYLSTQEDIEVVGEGASGKDAITKAHELKPDLILMDLLMDDMDGVEATTEIKKDLPQIKVV
MLTSFIEDKEVYRALDSGVDSYILKTTSASDIADAVRKTYEGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=503464 HWI23_RS08325 WP_001830439.1 1673515..1674144(-) (vraR) [Staphylococcus epidermidis strain UMCG350]
GTGGCGATTAAAGTTTTATTTGTTGATGATCATGAAATGGTAAGAATCGGTATTTCAAGCTATCTTTCAACTCAAGAAGA
TATAGAAGTAGTAGGTGAGGGTGCTTCTGGTAAAGATGCTATCACTAAAGCGCATGAGCTAAAACCAGATTTAATATTAA
TGGATTTACTTATGGACGATATGGATGGTGTAGAAGCAACTACTGAAATAAAAAAAGATTTACCTCAAATTAAAGTAGTC
ATGTTAACAAGCTTTATAGAGGATAAAGAAGTTTATCGTGCACTTGATTCTGGAGTAGATAGTTATATTTTAAAGACAAC
AAGTGCAAGTGATATAGCTGACGCTGTGCGTAAAACGTATGAAGGTGAATCAGTATTTGAACCAGAAGTGTTAGTAAAAA
TGCGCAATCGTATGAAAAAACGTGCCGAGCTTTATGAAATGTTGACAGAAAGAGAAATGGAGATCCTATTACTTATAGCT
AAAGGATACTCTAACCAAGAGATTGCAAGCGCCTCTCATATCACCATCAAAACAGTAAAAACTCATGTAAGTAACATACT
AAGTAAATTAGAAGTACAAGATCGAACACAAGCAGTAATATATGCGTTCCAGCATAATTTAATTCAATAA

Domains

Predicted by InterproScan.

Bacterial regulatory proteins, luxR family (GerE)

(147-202)

Response regulator receiver domain (Response_reg)

(5-116)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2G7HYX3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

94.737

100

0.947
  degU Bacillus subtilis subsp. subtilis str. 168

34.375

100

0.368