Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | HWI31_RS13475 | Genome accession | NZ_CP064572 |
| Coordinates | 2727637..2728983 (+) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus epidermidis strain UMCG358 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2693831..2748795 | 2727637..2728983 | within | 0 |
Gene organization within MGE regions
Location: 2693831..2748795
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI31_RS13295 (HWI31_13170) | - | 2693831..2694643 (-) | 813 | WP_002504699.1 | abortive infection system antitoxin AbiGi family protein | - |
| HWI31_RS13300 (HWI31_13175) | - | 2694834..2696348 (+) | 1515 | WP_002504700.1 | class I SAM-dependent DNA methyltransferase | - |
| HWI31_RS13305 (HWI31_13180) | - | 2696338..2697612 (+) | 1275 | WP_002504701.1 | restriction endonuclease subunit S | - |
| HWI31_RS13310 (HWI31_13185) | - | 2697596..2700715 (+) | 3120 | WP_002504702.1 | type I restriction endonuclease subunit R | - |
| HWI31_RS13315 (HWI31_13190) | - | 2700793..2701116 (-) | 324 | WP_001176049.1 | PepSY domain-containing protein | - |
| HWI31_RS13320 (HWI31_13195) | - | 2701510..2701731 (-) | 222 | WP_002504703.1 | hypothetical protein | - |
| HWI31_RS13325 (HWI31_13200) | - | 2701680..2702123 (-) | 444 | WP_000941333.1 | hypothetical protein | - |
| HWI31_RS13330 (HWI31_13205) | - | 2702185..2702712 (-) | 528 | WP_002504704.1 | hypothetical protein | - |
| HWI31_RS13335 (HWI31_13210) | - | 2702847..2703335 (-) | 489 | WP_000393586.1 | hypothetical protein | - |
| HWI31_RS13340 (HWI31_13215) | - | 2703351..2703641 (-) | 291 | WP_000065261.1 | hypothetical protein | - |
| HWI31_RS13345 (HWI31_13220) | - | 2703698..2704570 (-) | 873 | WP_000373149.1 | HTH domain-containing protein | - |
| HWI31_RS13350 (HWI31_13225) | - | 2704740..2705186 (-) | 447 | WP_002504705.1 | RadC family protein | - |
| HWI31_RS13355 (HWI31_13230) | - | 2705207..2705713 (-) | 507 | WP_000849085.1 | DUF1643 domain-containing protein | - |
| HWI31_RS13360 (HWI31_13235) | - | 2705729..2706040 (-) | 312 | WP_001083108.1 | DUF960 family protein | - |
| HWI31_RS13365 (HWI31_13240) | - | 2706136..2706474 (-) | 339 | WP_063964250.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI31_RS13370 (HWI31_13245) | ccrC | 2706580..2708256 (-) | 1677 | WP_002504707.1 | cassette chromosome recombinase CcrC | - |
| HWI31_RS13375 (HWI31_13250) | - | 2708481..2710124 (-) | 1644 | WP_002504708.1 | DUF5906 domain-containing protein | - |
| HWI31_RS13380 (HWI31_13255) | - | 2710121..2710492 (-) | 372 | WP_002437511.1 | hypothetical protein | - |
| HWI31_RS13385 (HWI31_13260) | - | 2710485..2711594 (-) | 1110 | WP_002437509.1 | DNA polymerase | - |
| HWI31_RS13390 (HWI31_13265) | - | 2711764..2713776 (-) | 2013 | WP_012088687.1 | hypothetical protein | - |
| HWI31_RS13395 (HWI31_13270) | - | 2713938..2714867 (-) | 930 | WP_002504713.1 | YafY family protein | - |
| HWI31_RS13400 (HWI31_13275) | - | 2714948..2715376 (+) | 429 | WP_000671997.1 | VOC family protein | - |
| HWI31_RS13405 (HWI31_13280) | - | 2715436..2716110 (-) | 675 | Protein_2599 | IS6 family transposase | - |
| HWI31_RS13410 (HWI31_13285) | - | 2716321..2717511 (+) | 1191 | WP_000716034.1 | YbfB/YjiJ family MFS transporter | - |
| HWI31_RS13415 (HWI31_13290) | - | 2717498..2718364 (+) | 867 | WP_002504710.1 | LysR family transcriptional regulator | - |
| HWI31_RS13420 (HWI31_13295) | - | 2718377..2719447 (+) | 1071 | WP_001054882.1 | nitronate monooxygenase family protein | - |
| HWI31_RS13425 (HWI31_13300) | - | 2719612..2719971 (+) | 360 | WP_000432280.1 | DUF4870 domain-containing protein | - |
| HWI31_RS13430 (HWI31_13305) | - | 2720209..2720982 (-) | 774 | WP_000998885.1 | hypothetical protein | - |
| HWI31_RS13435 (HWI31_13310) | - | 2721299..2721463 (-) | 165 | WP_001028954.1 | hypothetical protein | - |
| HWI31_RS13440 (HWI31_13315) | - | 2721668..2722501 (-) | 834 | WP_000694291.1 | CPBP family intramembrane glutamic endopeptidase | - |
| HWI31_RS13445 (HWI31_13320) | - | 2722538..2722864 (-) | 327 | WP_000624048.1 | helix-turn-helix domain-containing protein | - |
| HWI31_RS13450 (HWI31_13325) | - | 2723196..2723768 (-) | 573 | WP_000489177.1 | ADP-ribosyltransferase | - |
| HWI31_RS13455 (HWI31_13330) | - | 2723821..2724870 (-) | 1050 | WP_000613217.1 | hypothetical protein | - |
| HWI31_RS13460 (HWI31_13335) | ssb | 2725008..2725292 (+) | 285 | WP_000659554.1 | cassette chromosome ssDNA-binding protein | - |
| HWI31_RS13465 (HWI31_13340) | cch1 | 2725292..2727079 (+) | 1788 | WP_000181743.1 | cassette chromosome replicative helicase | - |
| HWI31_RS13470 (HWI31_13345) | - | 2727169..2727444 (+) | 276 | WP_001791132.1 | hypothetical protein | - |
| HWI31_RS13475 (HWI31_13350) | ccrA | 2727637..2728983 (+) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
| HWI31_RS13480 (HWI31_13355) | ccrB | 2729004..2730632 (+) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| HWI31_RS13485 (HWI31_13360) | - | 2731103..2731453 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI31_RS13490 (HWI31_13365) | - | 2731538..2731849 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| HWI31_RS13495 (HWI31_13370) | - | 2731868..2732389 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| HWI31_RS13500 (HWI31_13375) | - | 2732391..2732597 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| HWI31_RS13505 (HWI31_13380) | - | 2732590..2732913 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| HWI31_RS13510 (HWI31_13385) | - | 2733108..2735000 (+) | 1893 | WP_063964251.1 | site-specific integrase | - |
| HWI31_RS13515 (HWI31_13390) | - | 2735007..2735384 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| HWI31_RS13520 (HWI31_13395) | - | 2735622..2735987 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| HWI31_RS13525 (HWI31_13400) | - | 2735980..2738394 (+) | 2415 | WP_408020818.1 | heavy metal translocating P-type ATPase | - |
| HWI31_RS13530 (HWI31_13405) | - | 2738475..2739091 (+) | 617 | Protein_2624 | CadD family cadmium resistance transporter | - |
| HWI31_RS13535 (HWI31_13415) | - | 2739365..2740003 (-) | 639 | Protein_2625 | sulfite exporter TauE/SafE family protein | - |
| HWI31_RS13540 (HWI31_13420) | cstR | 2740003..2740263 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| HWI31_RS13545 (HWI31_13425) | - | 2740399..2741463 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| HWI31_RS13550 (HWI31_13430) | cstB | 2741496..2742830 (+) | 1335 | Protein_2628 | persulfide dioxygenase-sulfurtransferase CstB | - |
| HWI31_RS13555 (HWI31_13435) | - | 2742944..2744074 (-) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| HWI31_RS13560 (HWI31_13440) | psm-mec | 2744408..2744476 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| HWI31_RS13565 (HWI31_13445) | mecI | 2744561..2744932 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| HWI31_RS13570 (HWI31_13450) | mecR1 | 2744932..2746689 (-) | 1758 | WP_002504642.1 | beta-lactam sensor/signal transducer MecR1 | - |
| HWI31_RS13575 (HWI31_13455) | mecA | 2746786..2748795 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=503209 HWI31_RS13475 WP_000816499.1 2727637..2728983(+) (ccrA) [Staphylococcus epidermidis strain UMCG358]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=503209 HWI31_RS13475 WP_000816499.1 2727637..2728983(+) (ccrA) [Staphylococcus epidermidis strain UMCG358]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |