Detailed information NTG0503053

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI35_RS08315
• Genome accession: NZ_CP064557
• Coordinates: 1671567..1672613 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG362
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1666567..1677613

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI35_RS08285 (HWI35_08205)	-	1666951..1668192 (-)	1242	WP_001832467.1	aminopeptidase	-
HWI35_RS08290 (HWI35_08210)	-	1668194..1668409 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI35_RS08295 (HWI35_08215)	-	1668550..1669014 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI35_RS08300 (HWI35_08220)	-	1669022..1669306 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI35_RS08305 (HWI35_08225)	-	1669713..1670891 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI35_RS08310 (HWI35_08230)	vraR	1670948..1671577 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI35_RS08315 (HWI35_08235)	vraS	1671567..1672613 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI35_RS08320 (HWI35_08240)	liaF	1672610..1673311 (-)	702	WP_063964223.1	cell wall-active antibiotics response protein LiaF	-
HWI35_RS08325 (HWI35_08245)	-	1673326..1673712 (-)	387	WP_001830382.1	hypothetical protein	-
HWI35_RS08330 (HWI35_08250)	map	1673870..1674625 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI35_RS08335 (HWI35_08255)	-	1674799..1675785 (+)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI35_RS08340 (HWI35_08260)	isaB	1675936..1676472 (-)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=503053 HWI35_RS08315 WP_001830374.1 1671567..1672613(-) (vraS) [Staphylococcus epidermidis strain UMCG362]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=503053 HWI35_RS08315 WP_001830374.1 1671567..1672613(-) (vraS) [Staphylococcus epidermidis strain UMCG362]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92