Detailed information
Bioinformatically predicted
Overview
| Name | comK/comK1 | Type | Regulator |
| Locus tag | HWI35_RS03420 | Genome accession | NZ_CP064557 |
| Coordinates | 696276..696851 (+) | Length | 191 a.a. |
| NCBI ID | WP_001829272.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain UMCG362 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 697252..742487 | 696276..696851 | flank | 401 |
Gene organization within MGE regions
Location: 696276..742487
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI35_RS03420 (HWI35_03385) | comK/comK1 | 696276..696851 (+) | 576 | WP_001829272.1 | competence protein ComK | Regulator |
| HWI35_RS03435 (HWI35_03400) | - | 697252..698301 (-) | 1050 | WP_002504795.1 | site-specific integrase | - |
| HWI35_RS03440 (HWI35_03405) | - | 698412..698609 (+) | 198 | WP_002497576.1 | hypothetical protein | - |
| HWI35_RS03445 (HWI35_03410) | - | 698606..699013 (-) | 408 | WP_002497577.1 | TIR domain-containing protein | - |
| HWI35_RS03450 (HWI35_03415) | - | 699007..699444 (-) | 438 | WP_002497578.1 | DUF4231 domain-containing protein | - |
| HWI35_RS03455 (HWI35_03420) | - | 699556..700224 (-) | 669 | WP_002504794.1 | hypothetical protein | - |
| HWI35_RS03460 (HWI35_03425) | - | 700242..700700 (-) | 459 | WP_002504200.1 | ImmA/IrrE family metallo-endopeptidase | - |
| HWI35_RS03465 (HWI35_03430) | - | 700722..701036 (-) | 315 | WP_002504199.1 | helix-turn-helix transcriptional regulator | - |
| HWI35_RS03470 (HWI35_03435) | - | 701189..701401 (+) | 213 | WP_002456362.1 | helix-turn-helix transcriptional regulator | - |
| HWI35_RS03475 (HWI35_03440) | - | 701445..701585 (+) | 141 | WP_002485815.1 | hypothetical protein | - |
| HWI35_RS03480 (HWI35_03445) | - | 701578..701802 (-) | 225 | WP_002504198.1 | hypothetical protein | - |
| HWI35_RS03485 (HWI35_03450) | - | 701852..702592 (+) | 741 | WP_002504197.1 | phage repressor protein | - |
| HWI35_RS03490 (HWI35_03455) | - | 702605..702814 (+) | 210 | WP_001830281.1 | hypothetical protein | - |
| HWI35_RS03495 (HWI35_03460) | - | 702828..702974 (+) | 147 | WP_002504793.1 | hypothetical protein | - |
| HWI35_RS03500 (HWI35_03465) | - | 702961..703239 (-) | 279 | WP_002484728.1 | hypothetical protein | - |
| HWI35_RS03505 (HWI35_03470) | - | 703334..703510 (+) | 177 | WP_002484719.1 | hypothetical protein | - |
| HWI35_RS03510 (HWI35_03475) | - | 703572..703823 (+) | 252 | WP_002484751.1 | hypothetical protein | - |
| HWI35_RS03515 (HWI35_03480) | - | 703816..704301 (+) | 486 | WP_002484734.1 | siphovirus Gp157 family protein | - |
| HWI35_RS03520 (HWI35_03485) | - | 704302..704928 (+) | 627 | WP_002469464.1 | DUF1071 domain-containing protein | - |
| HWI35_RS03525 (HWI35_03490) | - | 704921..705337 (+) | 417 | WP_002484754.1 | single-stranded DNA-binding protein | - |
| HWI35_RS03530 (HWI35_03495) | - | 705351..706040 (+) | 690 | WP_002504792.1 | putative HNHc nuclease | - |
| HWI35_RS03535 (HWI35_03500) | - | 706018..706248 (+) | 231 | WP_002504791.1 | helix-turn-helix domain-containing protein | - |
| HWI35_RS03540 (HWI35_03505) | - | 706254..706469 (+) | 216 | WP_002504790.1 | helix-turn-helix domain-containing protein | - |
| HWI35_RS03545 (HWI35_03510) | - | 706456..707184 (+) | 729 | WP_002504789.1 | DnaD domain protein | - |
| HWI35_RS03550 (HWI35_03515) | - | 707190..707543 (+) | 354 | WP_002504788.1 | hypothetical protein | - |
| HWI35_RS03555 (HWI35_03520) | - | 707533..708780 (+) | 1248 | WP_002504787.1 | DnaB-like helicase C-terminal domain-containing protein | - |
| HWI35_RS03560 (HWI35_03525) | - | 708777..709007 (+) | 231 | WP_002504786.1 | hypothetical protein | - |
| HWI35_RS03565 (HWI35_03530) | - | 708976..709200 (+) | 225 | WP_002456377.1 | DUF3269 family protein | - |
| HWI35_RS03570 (HWI35_03535) | - | 709211..709627 (+) | 417 | WP_002504785.1 | DUF1064 domain-containing protein | - |
| HWI35_RS03575 (HWI35_03540) | - | 709614..709988 (+) | 375 | WP_002484718.1 | hypothetical protein | - |
| HWI35_RS03580 (HWI35_03545) | - | 709988..710179 (+) | 192 | WP_002484773.1 | hypothetical protein | - |
| HWI35_RS03585 (HWI35_03550) | - | 710180..710539 (+) | 360 | WP_002484760.1 | SA1788 family PVL leukocidin-associated protein | - |
| HWI35_RS03590 (HWI35_03555) | - | 710536..710988 (+) | 453 | WP_002484724.1 | DUF3310 domain-containing protein | - |
| HWI35_RS03595 (HWI35_03560) | - | 710978..711265 (+) | 288 | WP_002484753.1 | hypothetical protein | - |
| HWI35_RS03600 (HWI35_03565) | - | 711281..711961 (+) | 681 | WP_002504784.1 | hypothetical protein | - |
| HWI35_RS03605 (HWI35_03570) | - | 711958..712158 (+) | 201 | WP_002504783.1 | hypothetical protein | - |
| HWI35_RS03610 (HWI35_03575) | - | 712142..712495 (+) | 354 | WP_002504782.1 | hypothetical protein | - |
| HWI35_RS03615 (HWI35_03580) | - | 712476..712673 (+) | 198 | WP_002504781.1 | Lar family restriction alleviation protein | - |
| HWI35_RS03620 (HWI35_03585) | - | 712674..713201 (+) | 528 | WP_002504780.1 | dUTPase | - |
| HWI35_RS03625 (HWI35_03590) | - | 713363..713521 (+) | 159 | WP_002504779.1 | DUF1381 domain-containing protein | - |
| HWI35_RS03630 (HWI35_03595) | - | 713580..713858 (+) | 279 | WP_002504778.1 | hypothetical protein | - |
| HWI35_RS03635 (HWI35_03600) | rinB | 713851..714018 (+) | 168 | WP_002504777.1 | transcriptional activator RinB | - |
| HWI35_RS03640 (HWI35_03605) | - | 714018..714167 (+) | 150 | WP_002484731.1 | DUF1514 family protein | - |
| HWI35_RS03645 (HWI35_03610) | - | 714184..714630 (+) | 447 | WP_002484732.1 | transcriptional regulator | - |
| HWI35_RS03650 (HWI35_03615) | - | 715225..715575 (+) | 351 | WP_002504776.1 | HNH endonuclease | - |
| HWI35_RS03655 (HWI35_03620) | - | 715718..716188 (+) | 471 | WP_002484733.1 | phage terminase small subunit P27 family | - |
| HWI35_RS03660 (HWI35_03625) | - | 716181..717932 (+) | 1752 | WP_002484749.1 | terminase large subunit | - |
| HWI35_RS03665 (HWI35_03630) | - | 717944..718138 (+) | 195 | WP_002500102.1 | hypothetical protein | - |
| HWI35_RS03670 (HWI35_03635) | - | 718141..719373 (+) | 1233 | WP_002504774.1 | phage portal protein | - |
| HWI35_RS03675 (HWI35_03640) | - | 719363..719920 (+) | 558 | WP_002504773.1 | HK97 family phage prohead protease | - |
| HWI35_RS03680 (HWI35_03645) | - | 719960..721309 (+) | 1350 | WP_002504772.1 | phage major capsid protein | - |
| HWI35_RS03685 (HWI35_03650) | - | 721328..721669 (+) | 342 | WP_002484745.1 | head-tail connector protein | - |
| HWI35_RS03690 (HWI35_03655) | - | 721659..721988 (+) | 330 | WP_002484730.1 | hypothetical protein | - |
| HWI35_RS03695 (HWI35_03660) | - | 722102..722389 (+) | 288 | WP_002484720.1 | hypothetical protein | - |
| HWI35_RS03700 (HWI35_03665) | - | 722392..722796 (+) | 405 | WP_002484722.1 | hypothetical protein | - |
| HWI35_RS03705 (HWI35_03670) | - | 722809..723438 (+) | 630 | WP_002484765.1 | major tail protein | - |
| HWI35_RS03710 (HWI35_03675) | - | 723457..723642 (+) | 186 | WP_002484762.1 | hypothetical protein | - |
| HWI35_RS03715 (HWI35_03680) | gpG | 723706..724068 (+) | 363 | WP_002484709.1 | phage tail assembly chaperone G | - |
| HWI35_RS03720 | gpGT | 724113..724253 (+) | 141 | WP_002484764.1 | phage tail assembly chaperone GT | - |
| HWI35_RS03725 (HWI35_03685) | - | 724282..728838 (+) | 4557 | Protein_720 | peptidoglycan DD-metalloendopeptidase family protein | - |
| HWI35_RS03730 (HWI35_03690) | - | 728840..729673 (+) | 834 | WP_002504770.1 | phage tail domain-containing protein | - |
| HWI35_RS03735 (HWI35_03695) | - | 729683..731242 (+) | 1560 | WP_002504769.1 | prophage endopeptidase tail family protein | - |
| HWI35_RS03740 (HWI35_03700) | - | 731235..731408 (+) | 174 | WP_002456411.1 | hypothetical protein | - |
| HWI35_RS03745 (HWI35_03705) | - | 731424..733286 (+) | 1863 | WP_002504768.1 | M14 family metallopeptidase | - |
| HWI35_RS03750 (HWI35_03710) | - | 733286..734500 (+) | 1215 | WP_002504767.1 | BppU family phage baseplate upper protein | - |
| HWI35_RS03755 (HWI35_03715) | - | 734505..735128 (+) | 624 | WP_002504766.1 | poly-gamma-glutamate hydrolase family protein | - |
| HWI35_RS03760 (HWI35_03720) | - | 735125..735550 (+) | 426 | WP_002456415.1 | hypothetical protein | - |
| HWI35_RS03765 (HWI35_03725) | - | 735537..735944 (+) | 408 | WP_002504154.1 | hypothetical protein | - |
| HWI35_RS03770 (HWI35_03730) | - | 736070..736336 (+) | 267 | WP_002504765.1 | phage holin | - |
| HWI35_RS03775 (HWI35_03735) | - | 736336..737718 (+) | 1383 | WP_002504764.1 | N-acetylmuramoyl-L-alanine amidase | - |
| HWI35_RS03780 (HWI35_03740) | - | 737796..738722 (+) | 927 | WP_002504133.1 | hypothetical protein | - |
| HWI35_RS03785 (HWI35_03745) | - | 738915..739442 (+) | 528 | WP_002504240.1 | Panacea domain-containing protein | - |
| HWI35_RS03790 (HWI35_03750) | - | 739432..739830 (+) | 399 | WP_002504241.1 | hypothetical protein | - |
| HWI35_RS03795 | mobV | 740956..741495 (+) | 540 | Protein_734 | MobV family relaxase | - |
| HWI35_RS03800 (HWI35_03765) | - | 741697..741933 (+) | 237 | WP_001829451.1 | hypothetical protein | - |
| HWI35_RS03805 (HWI35_03770) | - | 742146..742487 (+) | 342 | WP_002456621.1 | fatty acid desaturase | - |
Sequence
Protein
Download Length: 191 a.a. Molecular weight: 22782.87 Da Isoelectric Point: 9.2887
>NTDB_id=503036 HWI35_RS03420 WP_001829272.1 696276..696851(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG362]
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
Nucleotide
Download Length: 576 bp
>NTDB_id=503036 HWI35_RS03420 WP_001829272.1 696276..696851(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG362]
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comK/comK1 | Staphylococcus aureus MW2 |
76.757 |
96.859 |
0.743 |
| comK/comK1 | Staphylococcus aureus N315 |
76.757 |
96.859 |
0.743 |