Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | HWI38_RS13275 | Genome accession | NZ_CP064545 |
| Coordinates | 2687390..2688736 (+) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus epidermidis strain UMCG365 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2653584..2708313 | 2687390..2688736 | within | 0 |
Gene organization within MGE regions
Location: 2653584..2708313
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI38_RS13095 (HWI38_12965) | - | 2653584..2654396 (-) | 813 | WP_002504699.1 | abortive infection system antitoxin AbiGi family protein | - |
| HWI38_RS13100 (HWI38_12970) | - | 2654587..2656101 (+) | 1515 | WP_002504700.1 | class I SAM-dependent DNA methyltransferase | - |
| HWI38_RS13105 (HWI38_12975) | - | 2656091..2657365 (+) | 1275 | WP_002504701.1 | restriction endonuclease subunit S | - |
| HWI38_RS13110 (HWI38_12980) | - | 2657349..2660468 (+) | 3120 | WP_002504702.1 | type I restriction endonuclease subunit R | - |
| HWI38_RS13115 (HWI38_12985) | - | 2660546..2660869 (-) | 324 | WP_001176049.1 | PepSY domain-containing protein | - |
| HWI38_RS13120 (HWI38_12990) | - | 2661263..2661484 (-) | 222 | WP_002504703.1 | hypothetical protein | - |
| HWI38_RS13125 (HWI38_12995) | - | 2661433..2661876 (-) | 444 | WP_000941333.1 | hypothetical protein | - |
| HWI38_RS13130 (HWI38_13000) | - | 2661938..2662465 (-) | 528 | WP_002504704.1 | hypothetical protein | - |
| HWI38_RS13135 (HWI38_13005) | - | 2662600..2663088 (-) | 489 | WP_000393586.1 | hypothetical protein | - |
| HWI38_RS13140 (HWI38_13010) | - | 2663104..2663394 (-) | 291 | WP_000065261.1 | hypothetical protein | - |
| HWI38_RS13145 (HWI38_13015) | - | 2663451..2664323 (-) | 873 | WP_000373149.1 | HTH domain-containing protein | - |
| HWI38_RS13150 (HWI38_13020) | - | 2664493..2664939 (-) | 447 | WP_002504705.1 | RadC family protein | - |
| HWI38_RS13155 (HWI38_13025) | - | 2664960..2665466 (-) | 507 | WP_000849085.1 | DUF1643 domain-containing protein | - |
| HWI38_RS13160 (HWI38_13030) | - | 2665482..2665793 (-) | 312 | WP_001083108.1 | DUF960 family protein | - |
| HWI38_RS13165 (HWI38_13035) | - | 2665889..2666227 (-) | 339 | WP_000171557.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI38_RS13170 (HWI38_13040) | ccrC | 2666333..2668009 (-) | 1677 | WP_002504707.1 | cassette chromosome recombinase CcrC | - |
| HWI38_RS13175 (HWI38_13045) | - | 2668234..2669877 (-) | 1644 | WP_002504708.1 | DUF5906 domain-containing protein | - |
| HWI38_RS13180 (HWI38_13050) | - | 2669874..2670245 (-) | 372 | WP_002437511.1 | hypothetical protein | - |
| HWI38_RS13185 (HWI38_13055) | - | 2670238..2671347 (-) | 1110 | WP_002437509.1 | DNA polymerase | - |
| HWI38_RS13190 (HWI38_13060) | - | 2671517..2673529 (-) | 2013 | WP_012088687.1 | hypothetical protein | - |
| HWI38_RS13195 (HWI38_13065) | - | 2673691..2674620 (-) | 930 | WP_002504713.1 | YafY family protein | - |
| HWI38_RS13200 (HWI38_13070) | - | 2674701..2675129 (+) | 429 | WP_000671997.1 | VOC family protein | - |
| HWI38_RS13205 (HWI38_13075) | - | 2675189..2675863 (-) | 675 | Protein_2559 | IS6 family transposase | - |
| HWI38_RS13210 (HWI38_13080) | - | 2676074..2677264 (+) | 1191 | WP_000716034.1 | YbfB/YjiJ family MFS transporter | - |
| HWI38_RS13215 (HWI38_13085) | - | 2677251..2678117 (+) | 867 | WP_002504710.1 | LysR family transcriptional regulator | - |
| HWI38_RS13220 (HWI38_13090) | - | 2678130..2679200 (+) | 1071 | WP_001054882.1 | nitronate monooxygenase family protein | - |
| HWI38_RS13225 (HWI38_13095) | - | 2679365..2679724 (+) | 360 | WP_000432280.1 | DUF4870 domain-containing protein | - |
| HWI38_RS13230 (HWI38_13100) | - | 2679962..2680735 (-) | 774 | WP_000998885.1 | hypothetical protein | - |
| HWI38_RS13235 (HWI38_13105) | - | 2681052..2681216 (-) | 165 | WP_001028954.1 | hypothetical protein | - |
| HWI38_RS13240 (HWI38_13110) | - | 2681421..2682254 (-) | 834 | WP_000694291.1 | CPBP family intramembrane glutamic endopeptidase | - |
| HWI38_RS13245 (HWI38_13115) | - | 2682291..2682617 (-) | 327 | WP_000624048.1 | helix-turn-helix domain-containing protein | - |
| HWI38_RS13250 (HWI38_13120) | - | 2682949..2683521 (-) | 573 | WP_000489177.1 | ADP-ribosyltransferase | - |
| HWI38_RS13255 (HWI38_13125) | - | 2683574..2684623 (-) | 1050 | WP_000613217.1 | hypothetical protein | - |
| HWI38_RS13260 (HWI38_13130) | ssb | 2684761..2685045 (+) | 285 | WP_000659554.1 | cassette chromosome ssDNA-binding protein | - |
| HWI38_RS13265 (HWI38_13135) | cch1 | 2685045..2686832 (+) | 1788 | WP_000181743.1 | cassette chromosome replicative helicase | - |
| HWI38_RS13270 (HWI38_13140) | - | 2686922..2687197 (+) | 276 | WP_001791132.1 | hypothetical protein | - |
| HWI38_RS13275 (HWI38_13145) | ccrA | 2687390..2688736 (+) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
| HWI38_RS13280 (HWI38_13150) | ccrB | 2688757..2690385 (+) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| HWI38_RS13285 (HWI38_13155) | - | 2690856..2691206 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI38_RS13290 (HWI38_13160) | - | 2691291..2691602 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| HWI38_RS13295 (HWI38_13165) | - | 2691621..2692142 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| HWI38_RS13300 (HWI38_13170) | - | 2692144..2692350 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| HWI38_RS13305 (HWI38_13175) | - | 2692343..2692666 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| HWI38_RS13310 (HWI38_13180) | - | 2692861..2694753 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| HWI38_RS13315 (HWI38_13185) | - | 2694760..2695137 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| HWI38_RS13320 (HWI38_13190) | - | 2695375..2695740 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| HWI38_RS13325 (HWI38_13195) | cadA | 2695733..2697913 (+) | 2181 | WP_053038472.1 | cadmium-translocating P-type ATPase CadA | - |
| HWI38_RS13330 (HWI38_13200) | - | 2697994..2698610 (+) | 617 | Protein_2584 | CadD family cadmium resistance transporter | - |
| HWI38_RS13335 (HWI38_13210) | - | 2698884..2699522 (-) | 639 | Protein_2585 | sulfite exporter TauE/SafE family protein | - |
| HWI38_RS13340 (HWI38_13215) | cstR | 2699522..2699782 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| HWI38_RS13345 (HWI38_13220) | - | 2699918..2700982 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| HWI38_RS13350 (HWI38_13225) | cstB | 2701014..2702348 (+) | 1335 | Protein_2588 | persulfide dioxygenase-sulfurtransferase CstB | - |
| HWI38_RS13355 (HWI38_13230) | - | 2702462..2703592 (-) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| HWI38_RS13360 (HWI38_13235) | psm-mec | 2703926..2703994 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| HWI38_RS13365 (HWI38_13240) | mecI | 2704079..2704450 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| HWI38_RS13370 (HWI38_13245) | mecR1 | 2704450..2706207 (-) | 1758 | WP_002504642.1 | beta-lactam sensor/signal transducer MecR1 | - |
| HWI38_RS13375 (HWI38_13250) | mecA | 2706304..2708313 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=502949 HWI38_RS13275 WP_000816499.1 2687390..2688736(+) (ccrA) [Staphylococcus epidermidis strain UMCG365]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=502949 HWI38_RS13275 WP_000816499.1 2687390..2688736(+) (ccrA) [Staphylococcus epidermidis strain UMCG365]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |