Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | HWI42_RS00395 | Genome accession | NZ_CP064533 |
| Coordinates | 86748..88097 (-) | Length | 449 a.a. |
| NCBI ID | WP_000815640.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain UMCG369 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 39711..93268 | 86748..88097 | within | 0 |
Gene organization within MGE regions
Location: 39711..93268
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI42_RS00160 (HWI42_00160) | ccrC | 39711..41387 (+) | 1677 | WP_002504707.1 | cassette chromosome recombinase CcrC | - |
| HWI42_RS00165 (HWI42_00165) | - | 41493..41831 (+) | 339 | WP_000171557.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI42_RS00170 (HWI42_00170) | - | 41927..42238 (+) | 312 | Protein_31 | DUF960 family protein | - |
| HWI42_RS00175 (HWI42_00175) | - | 42254..42760 (+) | 507 | WP_000849085.1 | DUF1643 domain-containing protein | - |
| HWI42_RS00180 (HWI42_00180) | - | 42781..43098 (+) | 318 | WP_130825069.1 | JAB domain-containing protein | - |
| HWI42_RS00185 (HWI42_00185) | - | 43217..44302 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| HWI42_RS00190 (HWI42_00190) | - | 44299..46191 (+) | 1893 | WP_002486148.1 | site-specific integrase | - |
| HWI42_RS00195 (HWI42_00195) | - | 46198..46575 (+) | 378 | WP_072474270.1 | DUF6262 family protein | - |
| HWI42_RS00200 (HWI42_00200) | - | 46726..47508 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| HWI42_RS00205 (HWI42_00205) | erm(A) | 47634..48365 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| HWI42_RS00210 (HWI42_00210) | - | 48400..48459 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| HWI42_RS00215 (HWI42_00215) | - | 48851..49513 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| HWI42_RS00220 (HWI42_00220) | - | 49742..49891 (+) | 150 | Protein_41 | JAB domain-containing protein | - |
| HWI42_RS00225 (HWI42_00225) | - | 50061..50933 (+) | 873 | WP_000373149.1 | HTH domain-containing protein | - |
| HWI42_RS00230 (HWI42_00230) | - | 50990..51280 (+) | 291 | WP_000065261.1 | hypothetical protein | - |
| HWI42_RS00235 (HWI42_00235) | - | 51296..51784 (+) | 489 | WP_000393586.1 | hypothetical protein | - |
| HWI42_RS00240 (HWI42_00240) | - | 51919..52446 (+) | 528 | WP_002504704.1 | hypothetical protein | - |
| HWI42_RS00245 (HWI42_00245) | - | 52508..52951 (+) | 444 | WP_070663618.1 | hypothetical protein | - |
| HWI42_RS00250 (HWI42_00250) | - | 52900..53121 (+) | 222 | WP_002504703.1 | hypothetical protein | - |
| HWI42_RS00255 (HWI42_00255) | - | 53273..53839 (+) | 567 | WP_145382879.1 | peptidase | - |
| HWI42_RS00260 (HWI42_00260) | - | 53917..57036 (-) | 3120 | WP_070663620.1 | type I restriction endonuclease subunit R | - |
| HWI42_RS00265 (HWI42_00265) | - | 57020..58339 (-) | 1320 | WP_070663622.1 | restriction endonuclease subunit S | - |
| HWI42_RS00270 (HWI42_00270) | - | 58329..59843 (-) | 1515 | WP_070663624.1 | class I SAM-dependent DNA methyltransferase | - |
| HWI42_RS00275 (HWI42_00275) | - | 59938..63171 (-) | 3234 | WP_083310611.1 | DEAD/DEAH box helicase | - |
| HWI42_RS00280 (HWI42_00280) | - | 63171..64364 (-) | 1194 | WP_070663626.1 | RNA polymerase sigma factor RpoD/SigA | - |
| HWI42_RS00285 (HWI42_00285) | - | 64619..65101 (-) | 483 | WP_070663628.1 | hypothetical protein | - |
| HWI42_RS00290 (HWI42_00290) | - | 65104..66711 (-) | 1608 | WP_070663630.1 | N-6 DNA methylase | - |
| HWI42_RS00295 (HWI42_00295) | - | 67136..68086 (-) | 951 | Protein_56 | transposase | - |
| HWI42_RS00300 (HWI42_00300) | - | 68207..68776 (+) | 570 | WP_002470562.1 | hypothetical protein | - |
| HWI42_RS00305 (HWI42_00305) | - | 68821..69978 (+) | 1158 | WP_002485721.1 | hypothetical protein | - |
| HWI42_RS00310 (HWI42_00310) | - | 70161..70433 (+) | 273 | WP_002501902.1 | hypothetical protein | - |
| HWI42_RS00315 (HWI42_00315) | - | 70463..71137 (+) | 675 | WP_002501901.1 | IS6-like element IS257 family transposase | - |
| HWI42_RS00320 (HWI42_00320) | lspA | 71165..71617 (-) | 453 | WP_164071529.1 | signal peptidase II | - |
| HWI42_RS00325 (HWI42_00325) | - | 71777..72178 (+) | 402 | WP_057504659.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| HWI42_RS00330 (HWI42_00330) | - | 72432..73199 (+) | 768 | WP_057504658.1 | ZIP family metal transporter | - |
| HWI42_RS00335 (HWI42_00335) | - | 73456..75864 (+) | 2409 | WP_107362604.1 | heavy metal translocating P-type ATPase | - |
| HWI42_RS00340 (HWI42_00340) | - | 76080..76754 (-) | 675 | WP_031885605.1 | IS6-like element IS257 family transposase | - |
| HWI42_RS00345 (HWI42_00345) | - | 77019..77762 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| HWI42_RS00350 (HWI42_00350) | - | 77859..78287 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| HWI42_RS00355 (HWI42_00355) | mecA | 78333..80342 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| HWI42_RS00360 (HWI42_00360) | - | 80439..81425 (+) | 987 | WP_001549960.1 | beta-lactam sensor/signal transducer MecR1 | - |
| HWI42_RS00365 (HWI42_00365) | - | 81415..81657 (+) | 243 | Protein_70 | type I restriction enzyme endonuclease domain-containing protein | - |
| HWI42_RS00370 (HWI42_00370) | - | 81648..83258 (-) | 1611 | Protein_71 | IS1182 family transposase | - |
| HWI42_RS00375 (HWI42_00375) | - | 83307..83813 (-) | 507 | WP_001092194.1 | DUF1643 domain-containing protein | - |
| HWI42_RS00380 (HWI42_00380) | - | 83828..84139 (-) | 312 | WP_000700851.1 | DUF960 family protein | - |
| HWI42_RS00385 (HWI42_00385) | - | 84226..84576 (-) | 351 | WP_000849672.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI42_RS00390 (HWI42_00390) | ccrB | 85098..86726 (-) | 1629 | WP_001186608.1 | cassette chromosome recombinase CcrB | Machinery gene |
| HWI42_RS00395 (HWI42_00395) | ccrA | 86748..88097 (-) | 1350 | WP_000815640.1 | cassette chromosome recombinase CcrA | Machinery gene |
| HWI42_RS00400 (HWI42_00400) | cch1 | 88331..90124 (-) | 1794 | WP_000079473.1 | cassette chromosome replicative helicase | - |
| HWI42_RS00405 (HWI42_00405) | ssb | 90124..90420 (-) | 297 | WP_000273823.1 | cassette chromosome ssDNA-binding protein | - |
| HWI42_RS00410 (HWI42_00410) | - | 90613..91659 (-) | 1047 | WP_001042023.1 | hypothetical protein | - |
| HWI42_RS00415 (HWI42_00415) | - | 92114..93268 (+) | 1155 | WP_000912116.1 | ATP-binding protein | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52663.34 Da Isoelectric Point: 9.9639
>NTDB_id=502770 HWI42_RS00395 WP_000815640.1 86748..88097(-) (ccrA) [Staphylococcus epidermidis strain UMCG369]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=502770 HWI42_RS00395 WP_000815640.1 86748..88097(-) (ccrA) [Staphylococcus epidermidis strain UMCG369]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
97.55 |
100 |
0.976 |
| ccrA | Staphylococcus aureus COL |
75.947 |
100 |
0.759 |