Detailed information NTG0502722

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI44_RS08310
• Genome accession: NZ_CP064525
• Coordinates: 1670236..1671282 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG371
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1665236..1676282

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI44_RS08280 (HWI44_08200)	-	1665620..1666861 (-)	1242	WP_001832467.1	aminopeptidase	-
HWI44_RS08285 (HWI44_08205)	-	1666863..1667078 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI44_RS08290 (HWI44_08210)	-	1667219..1667683 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI44_RS08295 (HWI44_08215)	-	1667691..1667975 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI44_RS08300 (HWI44_08220)	-	1668382..1669560 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI44_RS08305 (HWI44_08225)	vraR	1669617..1670246 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI44_RS08310 (HWI44_08230)	vraS	1670236..1671282 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI44_RS08315 (HWI44_08235)	liaF	1671279..1671980 (-)	702	WP_063964223.1	cell wall-active antibiotics response protein LiaF	-
HWI44_RS08320 (HWI44_08240)	-	1671995..1672381 (-)	387	WP_001830382.1	hypothetical protein	-
HWI44_RS08325 (HWI44_08245)	map	1672539..1673294 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI44_RS08330 (HWI44_08250)	-	1673468..1674454 (+)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI44_RS08335 (HWI44_08255)	isaB	1674605..1675141 (-)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=502722 HWI44_RS08310 WP_001830374.1 1670236..1671282(-) (vraS) [Staphylococcus epidermidis strain UMCG371]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=502722 HWI44_RS08310 WP_001830374.1 1670236..1671282(-) (vraS) [Staphylococcus epidermidis strain UMCG371]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92