Detailed information NTG0502521

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI49_RS04395
• Genome accession: NZ_CP064508
• Coordinates: 936016..937062 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG376
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 931016..942062

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI49_RS04370 (HWI49_04350)	isaB	932157..932693 (+)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-
HWI49_RS04375 (HWI49_04355)	-	932844..933830 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI49_RS04380 (HWI49_04360)	map	934004..934759 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI49_RS04385 (HWI49_04365)	-	934917..935303 (+)	387	WP_001830382.1	hypothetical protein	-
HWI49_RS04390 (HWI49_04370)	liaF	935318..936019 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
HWI49_RS04395 (HWI49_04375)	vraS	936016..937062 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI49_RS04400 (HWI49_04380)	vraR	937052..937681 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI49_RS04405 (HWI49_04385)	-	937738..938916 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI49_RS04410 (HWI49_04390)	-	939323..939607 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI49_RS04415 (HWI49_04395)	-	939615..940079 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI49_RS04420 (HWI49_04400)	-	940220..940435 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI49_RS04425 (HWI49_04405)	-	940437..941678 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=502521 HWI49_RS04395 WP_001830374.1 936016..937062(+) (vraS) [Staphylococcus epidermidis strain UMCG376]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=502521 HWI49_RS04395 WP_001830374.1 936016..937062(+) (vraS) [Staphylococcus epidermidis strain UMCG376]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92