Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   HWI50_RS04540 Genome accession   NZ_CP064504
Coordinates   976235..976864 (+) Length   209 a.a.
NCBI ID   WP_001830439.1    Uniprot ID   A0A2G7HYX3
Organism   Staphylococcus epidermidis strain UMCG377     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 971235..981864
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HWI50_RS04510 (HWI50_04505) isaB 971340..971876 (+) 537 WP_001830372.1 immunodominant staphylococcal antigen IsaB family protein -
  HWI50_RS04515 (HWI50_04510) - 972027..973013 (-) 987 WP_002457091.1 aromatic acid exporter family protein -
  HWI50_RS04520 (HWI50_04515) map 973187..973942 (+) 756 WP_002457092.1 type I methionyl aminopeptidase -
  HWI50_RS04525 (HWI50_04520) - 974100..974486 (+) 387 WP_001830382.1 hypothetical protein -
  HWI50_RS04530 (HWI50_04525) liaF 974501..975202 (+) 702 WP_002457093.1 cell wall-active antibiotics response protein LiaF -
  HWI50_RS04535 (HWI50_04530) vraS 975199..976245 (+) 1047 WP_002486322.1 sensor histidine kinase Regulator
  HWI50_RS04540 (HWI50_04535) vraR 976235..976864 (+) 630 WP_001830439.1 two-component system response regulator VraR Regulator
  HWI50_RS04545 (HWI50_04540) - 976921..978099 (-) 1179 WP_001830411.1 YihY/virulence factor BrkB family protein -
  HWI50_RS04550 (HWI50_04545) - 978506..978790 (-) 285 WP_001830401.1 YtxH domain-containing protein -
  HWI50_RS04555 (HWI50_04550) - 978798..979262 (-) 465 WP_001830437.1 low molecular weight protein-tyrosine-phosphatase -
  HWI50_RS04560 (HWI50_04555) - 979403..979618 (+) 216 WP_001830421.1 DUF1128 domain-containing protein -
  HWI50_RS04565 (HWI50_04560) - 979620..980861 (+) 1242 WP_002457094.1 aminopeptidase -
  HWI50_RS04570 (HWI50_04565) - 980941..981471 (+) 531 WP_001830371.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23584.19 Da        Isoelectric Point: 4.7166

>NTDB_id=502486 HWI50_RS04540 WP_001830439.1 976235..976864(+) (vraR) [Staphylococcus epidermidis strain UMCG377]
MAIKVLFVDDHEMVRIGISSYLSTQEDIEVVGEGASGKDAITKAHELKPDLILMDLLMDDMDGVEATTEIKKDLPQIKVV
MLTSFIEDKEVYRALDSGVDSYILKTTSASDIADAVRKTYEGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=502486 HWI50_RS04540 WP_001830439.1 976235..976864(+) (vraR) [Staphylococcus epidermidis strain UMCG377]
GTGGCGATTAAAGTTTTATTTGTTGATGATCATGAAATGGTAAGAATCGGTATTTCAAGCTATCTTTCAACTCAAGAAGA
TATAGAAGTAGTAGGTGAGGGTGCTTCTGGTAAAGATGCTATCACTAAAGCGCATGAGCTAAAACCAGATTTAATATTAA
TGGATTTACTTATGGACGATATGGATGGTGTAGAAGCAACTACTGAAATAAAAAAAGATTTACCTCAAATTAAAGTAGTC
ATGTTAACAAGCTTTATAGAGGATAAAGAAGTTTATCGTGCACTTGATTCTGGAGTAGATAGTTATATTTTAAAGACAAC
AAGTGCAAGTGATATAGCTGACGCTGTGCGTAAAACGTATGAAGGTGAATCAGTATTTGAACCAGAAGTGTTAGTAAAAA
TGCGCAATCGTATGAAAAAACGTGCCGAGCTTTATGAAATGTTGACAGAAAGAGAAATGGAGATCCTATTACTTATAGCT
AAAGGATACTCTAACCAAGAGATTGCAAGCGCCTCTCATATCACCATCAAAACAGTAAAAACTCATGTAAGTAACATACT
AAGTAAATTAGAAGTACAAGATCGAACACAAGCAGTAATATATGCGTTCCAGCATAATTTAATTCAATAA

Domains

Predicted by InterproScan.

Bacterial regulatory proteins, luxR family (GerE)

(147-202)

Response regulator receiver domain (Response_reg)

(5-116)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2G7HYX3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

94.737

100

0.947
  degU Bacillus subtilis subsp. subtilis str. 168

34.375

100

0.368