Detailed information NTG0502413

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI52_RS04480
• Genome accession: NZ_CP064498
• Coordinates: 963632..964678 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG379
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 958632..969678

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI52_RS04455 (HWI52_04435)	isaB	959773..960309 (+)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-
HWI52_RS04460 (HWI52_04440)	-	960460..961446 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI52_RS04465 (HWI52_04445)	map	961620..962375 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI52_RS04470 (HWI52_04450)	-	962533..962919 (+)	387	WP_002489903.1	hypothetical protein	-
HWI52_RS04475 (HWI52_04455)	liaF	962934..963635 (+)	702	WP_002473931.1	cell wall-active antibiotics response protein LiaF	-
HWI52_RS04480 (HWI52_04460)	vraS	963632..964678 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI52_RS04485 (HWI52_04465)	vraR	964668..965297 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI52_RS04490 (HWI52_04470)	-	965354..966532 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI52_RS04495 (HWI52_04475)	-	966939..967223 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI52_RS04500 (HWI52_04480)	-	967231..967695 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI52_RS04505 (HWI52_04485)	-	967836..968051 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI52_RS04510 (HWI52_04490)	-	968053..969294 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=502413 HWI52_RS04480 WP_001830374.1 963632..964678(+) (vraS) [Staphylococcus epidermidis strain UMCG379]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=502413 HWI52_RS04480 WP_001830374.1 963632..964678(+) (vraS) [Staphylococcus epidermidis strain UMCG379]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTTAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTGTTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCATTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92