Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | HWI55_RS00290 | Genome accession | NZ_CP064485 |
| Coordinates | 64187..65815 (-) | Length | 542 a.a. |
| NCBI ID | WP_407567791.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain UMCG382 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 34927..80786 | 64187..65815 | within | 0 |
| SCCmec | 64187..104479 | 64187..65815 | within | 0 |
Gene organization within MGE regions
Location: 34927..104479
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI55_RS00150 (HWI55_00150) | - | 35838..36407 (-) | 570 | WP_012087790.1 | TetR/AcrR family transcriptional regulator | - |
| HWI55_RS00155 (HWI55_00155) | - | 36757..37701 (-) | 945 | WP_002484621.1 | glycine betaine ABC transporter substrate-binding protein | - |
| HWI55_RS00160 (HWI55_00160) | - | 37725..40406 (-) | 2682 | WP_002484615.1 | MMPL family transporter | - |
| HWI55_RS00165 (HWI55_00165) | - | 40782..41135 (+) | 354 | WP_002487778.1 | hypothetical protein | - |
| HWI55_RS00170 (HWI55_00170) | - | 41380..42234 (-) | 855 | WP_223297891.1 | sensor histidine kinase KdpD | - |
| HWI55_RS00175 (HWI55_00175) | - | 42325..43080 (-) | 756 | WP_002487777.1 | ABC transporter permease | - |
| HWI55_RS00180 (HWI55_00180) | - | 43073..43987 (-) | 915 | WP_002487779.1 | ATP-binding cassette domain-containing protein | - |
| HWI55_RS00185 (HWI55_00185) | - | 44078..44746 (-) | 669 | WP_002487782.1 | response regulator transcription factor | - |
| HWI55_RS00190 (HWI55_00190) | - | 45356..46774 (-) | 1419 | WP_012087795.1 | aspartate aminotransferase family protein | - |
| HWI55_RS00195 (HWI55_00195) | - | 46863..47075 (-) | 213 | WP_002498809.1 | DUF1958 domain-containing protein | - |
| HWI55_RS00200 (HWI55_00200) | - | 47721..47924 (+) | 204 | WP_002487774.1 | hypothetical protein | - |
| HWI55_RS00205 (HWI55_00205) | - | 48232..48708 (-) | 477 | WP_230372680.1 | HEPN domain-containing protein | - |
| HWI55_RS00210 (HWI55_00210) | - | 48705..49337 (-) | 633 | WP_012087797.1 | hypothetical protein | - |
| HWI55_RS00215 (HWI55_00215) | - | 49471..49754 (+) | 284 | Protein_40 | type I restriction-modification system subunit M N-terminal domain-containing protein | - |
| HWI55_RS00220 (HWI55_00220) | - | 49973..50899 (-) | 927 | WP_012087799.1 | NAD-dependent epimerase/dehydratase family protein | - |
| HWI55_RS00225 | - | 50912..52393 (-) | 1482 | WP_064585175.1 | glycosyltransferase | - |
| HWI55_RS00230 | - | 52446..52568 (-) | 123 | WP_257473759.1 | hypothetical protein | - |
| HWI55_RS00235 (HWI55_00230) | - | 53278..55545 (+) | 2268 | WP_012102514.1 | CDP-glycerol:glycerophosphate glycerophosphotransferase | - |
| HWI55_RS00240 (HWI55_00235) | - | 55902..56656 (+) | 755 | Protein_45 | transposase | - |
| HWI55_RS00245 (HWI55_00240) | - | 56731..59604 (-) | 2874 | WP_012086603.1 | CDP-glycerol glycerophosphotransferase family protein | - |
| HWI55_RS00250 (HWI55_00245) | galU | 59730..60495 (-) | 766 | Protein_47 | UTP--glucose-1-phosphate uridylyltransferase GalU | - |
| HWI55_RS00255 (HWI55_00250) | - | 60912..61043 (-) | 132 | WP_257473760.1 | hypothetical protein | - |
| HWI55_RS00260 | - | 61169..61284 (+) | 116 | Protein_49 | type I restriction enzyme endonuclease domain-containing protein | - |
| HWI55_RS00265 (HWI55_00255) | - | 61340..61837 (-) | 498 | WP_012086596.1 | hypothetical protein | - |
| HWI55_RS00270 (HWI55_00260) | - | 61844..62122 (-) | 279 | WP_012086594.1 | hypothetical protein | - |
| HWI55_RS00275 (HWI55_00265) | - | 62420..62923 (-) | 504 | WP_012086592.1 | DUF1643 domain-containing protein | - |
| HWI55_RS00280 (HWI55_00270) | - | 62938..63249 (-) | 312 | WP_000700851.1 | DUF960 family protein | - |
| HWI55_RS00285 (HWI55_00275) | - | 63336..63686 (-) | 351 | WP_000849672.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI55_RS00290 (HWI55_00280) | ccrB | 64187..65815 (-) | 1629 | WP_407567791.1 | cassette chromosome recombinase CcrB | Machinery gene |
| HWI55_RS00295 (HWI55_00285) | ccrA | 65812..67173 (-) | 1362 | WP_001631036.1 | cassette chromosome recombinase CcrA | Machinery gene |
| HWI55_RS00300 (HWI55_00290) | - | 67360..67989 (-) | 630 | Protein_57 | hypothetical protein | - |
| HWI55_RS00305 (HWI55_00295) | - | 67998..68336 (+) | 339 | Protein_58 | recombinase family protein | - |
| HWI55_RS00310 (HWI55_00300) | - | 68448..68807 (-) | 360 | WP_001631039.1 | hypothetical protein | - |
| HWI55_RS00315 (HWI55_00305) | - | 69014..69340 (+) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| HWI55_RS00320 (HWI55_00310) | - | 69670..71595 (+) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| HWI55_RS00325 (HWI55_00315) | - | 72821..74077 (+) | 1257 | WP_000566670.1 | MrcB family domain-containing protein | - |
| HWI55_RS00330 (HWI55_00320) | - | 74492..74731 (+) | 240 | WP_001282728.1 | hypothetical protein | - |
| HWI55_RS00335 (HWI55_00325) | - | 74763..75437 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| HWI55_RS00340 (HWI55_00330) | - | 75528..76511 (-) | 984 | Protein_65 | protein rep | - |
| HWI55_RS00345 (HWI55_00335) | mobV | 76756..78018 (-) | 1263 | WP_000119405.1 | MobV family relaxase | - |
| HWI55_RS00350 (HWI55_00340) | bleO | 78528..78932 (-) | 405 | WP_001242578.1 | bleomycin binding protein | - |
| HWI55_RS00355 (HWI55_00345) | aadD1 | 79149..79919 (-) | 771 | WP_001795128.1 | aminoglycoside O-nucleotidyltransferase ANT(4')-Ia | - |
| HWI55_RS00360 (HWI55_00350) | - | 80112..80786 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| HWI55_RS00365 (HWI55_00355) | - | 80822..81211 (+) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| HWI55_RS00370 (HWI55_00360) | - | 82008..82751 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| HWI55_RS00375 (HWI55_00365) | - | 82848..83276 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| HWI55_RS00380 (HWI55_00370) | mecA | 83322..85331 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| HWI55_RS00385 (HWI55_00375) | mecR1 | 85427..87184 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| HWI55_RS00390 (HWI55_00380) | mecI | 87184..87555 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| HWI55_RS00395 (HWI55_00385) | psm-mec | 87640..87708 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| HWI55_RS00400 (HWI55_00390) | - | 88042..89172 (+) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| HWI55_RS00405 (HWI55_00395) | cstB | 89286..90620 (-) | 1335 | Protein_78 | persulfide dioxygenase-sulfurtransferase CstB | - |
| HWI55_RS00410 (HWI55_00400) | - | 90653..91717 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| HWI55_RS00415 (HWI55_00405) | cstR | 91853..92113 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| HWI55_RS00420 (HWI55_00410) | - | 92113..92751 (+) | 639 | Protein_81 | sulfite exporter TauE/SafE family protein | - |
| HWI55_RS00425 (HWI55_00420) | - | 93025..93641 (-) | 617 | Protein_82 | CadD family cadmium resistance transporter | - |
| HWI55_RS00430 (HWI55_00425) | - | 93722..96136 (-) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| HWI55_RS00435 (HWI55_00430) | - | 96129..96494 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| HWI55_RS00440 (HWI55_00435) | - | 96732..97109 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| HWI55_RS00445 (HWI55_00440) | - | 97116..99008 (-) | 1893 | WP_002485298.1 | site-specific integrase | - |
| HWI55_RS00450 (HWI55_00445) | - | 99203..99526 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| HWI55_RS00455 (HWI55_00450) | - | 99519..99725 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| HWI55_RS00460 (HWI55_00455) | - | 99727..100248 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| HWI55_RS00465 (HWI55_00460) | - | 100267..100578 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| HWI55_RS00470 (HWI55_00465) | - | 100663..101013 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI55_RS00475 (HWI55_00470) | ccrB | 101484..103112 (-) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| HWI55_RS00480 (HWI55_00475) | ccrA | 103133..104479 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62421.66 Da Isoelectric Point: 9.5131
>NTDB_id=502292 HWI55_RS00290 WP_407567791.1 64187..65815(-) (ccrB) [Staphylococcus epidermidis strain UMCG382]
MKQLKKKRIGLYARVSTEMQTDGYSIQGQLNQLTEYCQFQGYEVVNEYTDRGISGKTMQRPELQRMLKDANEGKLDCIMV
YKTNRLARNTSDLLNIVEELYKINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNTIVENVYNGQRQRAIEGYYQGNL
PLGYDKVPDSKKELMINQHEANIVKYIFDSYAKGHGYCKIANALNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDRNLWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEKSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILSYQDELNQINNQIYQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTIIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLPSTSSLFLPQTLYITIE
MKQLKKKRIGLYARVSTEMQTDGYSIQGQLNQLTEYCQFQGYEVVNEYTDRGISGKTMQRPELQRMLKDANEGKLDCIMV
YKTNRLARNTSDLLNIVEELYKINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNTIVENVYNGQRQRAIEGYYQGNL
PLGYDKVPDSKKELMINQHEANIVKYIFDSYAKGHGYCKIANALNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDRNLWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEKSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILSYQDELNQINNQIYQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTIIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLPSTSSLFLPQTLYITIE
Nucleotide
Download Length: 1629 bp
>NTDB_id=502292 HWI55_RS00290 WP_407567791.1 64187..65815(-) (ccrB) [Staphylococcus epidermidis strain UMCG382]
ATGAAACAACTCAAAAAGAAACGTATTGGATTATATGCACGTGTATCGACTGAAATGCAAACGGATGGTTACAGTATTCA
AGGTCAATTGAATCAACTTACAGAGTATTGTCAATTTCAAGGCTATGAAGTCGTCAATGAATACACCGATCGTGGTATAT
CAGGTAAAACAATGCAACGTCCAGAATTACAACGTATGTTAAAAGATGCCAACGAAGGTAAATTAGATTGTATTATGGTC
TACAAAACAAATCGTTTAGCTAGAAATACCTCAGATTTGTTAAATATTGTCGAGGAATTGTATAAGATTAATGTCGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCCAGTTCAACAGGTAAATTGATGCTCCAAATTTTAGCCAGCTTCGCAGAAT
TTGAACGTAATACGATTGTAGAGAATGTCTACAATGGCCAAAGACAACGTGCTATTGAAGGTTATTATCAAGGTAATTTA
CCTCTAGGCTACGATAAAGTACCTGACAGTAAAAAAGAGCTCATGATCAATCAACATGAAGCGAATATTGTTAAATATAT
TTTTGATTCATACGCTAAAGGTCATGGTTATTGTAAGATTGCGAACGCATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCTTTTAGTATTTCGTCCATTACCTACATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCTGATGGTAAACATGCGCCTATTATTGA
TAGAAACCTATGGGATAAAGTACAGTTTAAACGTCAAGAGAGTCGCAAGAAACCACAAGTTCACGGCAAAGGAACAAACC
TACTGACTGGGATTGTAAAATGTCCGAAATGTGGTGCAGCAATGGCGGCAAGTAATACAACTAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTACTCATGTAGCAATTTTAGAAATAAAGGTTCAAAAGTTTGTTCTGCCAATAGCGTTAG
AGCAGATGTACTAGAAAAATATGTTATGGATCAGATATTGGAAATTATCAAAAGCAAAAAGGTATTGAAGCAATTGGTTG
AAAAGGTAAATGAAAAAAGTCAAATAGACGTCTCTTCTTTGAACCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCAAAAATGCATACATTAACGAAAACTATTGAAGACTCACCTGACTTAGATAGCGTATTAAAACCAACAATACT
TAGCTACCAAGATGAATTGAATCAAATAAATAATCAAATCTATCAACTAGAACAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCGAATGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAATCATCGATCGCATTGACATAAGAAAAGATGAGCATCATAAGAAGCAATTTTATGTTACGCTCAAGTT
AAATAATGATATAATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCCTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA
ATGAAACAACTCAAAAAGAAACGTATTGGATTATATGCACGTGTATCGACTGAAATGCAAACGGATGGTTACAGTATTCA
AGGTCAATTGAATCAACTTACAGAGTATTGTCAATTTCAAGGCTATGAAGTCGTCAATGAATACACCGATCGTGGTATAT
CAGGTAAAACAATGCAACGTCCAGAATTACAACGTATGTTAAAAGATGCCAACGAAGGTAAATTAGATTGTATTATGGTC
TACAAAACAAATCGTTTAGCTAGAAATACCTCAGATTTGTTAAATATTGTCGAGGAATTGTATAAGATTAATGTCGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCCAGTTCAACAGGTAAATTGATGCTCCAAATTTTAGCCAGCTTCGCAGAAT
TTGAACGTAATACGATTGTAGAGAATGTCTACAATGGCCAAAGACAACGTGCTATTGAAGGTTATTATCAAGGTAATTTA
CCTCTAGGCTACGATAAAGTACCTGACAGTAAAAAAGAGCTCATGATCAATCAACATGAAGCGAATATTGTTAAATATAT
TTTTGATTCATACGCTAAAGGTCATGGTTATTGTAAGATTGCGAACGCATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCTTTTAGTATTTCGTCCATTACCTACATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCTGATGGTAAACATGCGCCTATTATTGA
TAGAAACCTATGGGATAAAGTACAGTTTAAACGTCAAGAGAGTCGCAAGAAACCACAAGTTCACGGCAAAGGAACAAACC
TACTGACTGGGATTGTAAAATGTCCGAAATGTGGTGCAGCAATGGCGGCAAGTAATACAACTAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTACTCATGTAGCAATTTTAGAAATAAAGGTTCAAAAGTTTGTTCTGCCAATAGCGTTAG
AGCAGATGTACTAGAAAAATATGTTATGGATCAGATATTGGAAATTATCAAAAGCAAAAAGGTATTGAAGCAATTGGTTG
AAAAGGTAAATGAAAAAAGTCAAATAGACGTCTCTTCTTTGAACCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCAAAAATGCATACATTAACGAAAACTATTGAAGACTCACCTGACTTAGATAGCGTATTAAAACCAACAATACT
TAGCTACCAAGATGAATTGAATCAAATAAATAATCAAATCTATCAACTAGAACAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCGAATGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAATCATCGATCGCATTGACATAAGAAAAGATGAGCATCATAAGAAGCAATTTTATGTTACGCTCAAGTT
AAATAATGATATAATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCCTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
72.509 |
100 |
0.725 |