Detailed information NTG0502208

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI58_RS08490
• Genome accession: NZ_CP064473
• Coordinates: 1761339..1762385 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG386
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1756339..1767385

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI58_RS08460 (HWI58_08380)	-	1756723..1757964 (-)	1242	WP_001832467.1	aminopeptidase	-
HWI58_RS08465 (HWI58_08385)	-	1757966..1758181 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI58_RS08470 (HWI58_08390)	-	1758322..1758786 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI58_RS08475 (HWI58_08395)	-	1758794..1759078 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI58_RS08480 (HWI58_08400)	-	1759485..1760663 (+)	1179	WP_408021128.1	YihY/virulence factor BrkB family protein	-
HWI58_RS08485 (HWI58_08405)	vraR	1760720..1761349 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI58_RS08490 (HWI58_08410)	vraS	1761339..1762385 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI58_RS08495 (HWI58_08415)	liaF	1762382..1763083 (-)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
HWI58_RS08500 (HWI58_08420)	-	1763098..1763484 (-)	387	WP_001830382.1	hypothetical protein	-
HWI58_RS08505 (HWI58_08425)	map	1763642..1764397 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI58_RS08510 (HWI58_08430)	-	1764571..1765557 (+)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI58_RS08515 (HWI58_08435)	isaB	1765708..1766244 (-)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=502208 HWI58_RS08490 WP_001830374.1 1761339..1762385(-) (vraS) [Staphylococcus epidermidis strain UMCG386]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=502208 HWI58_RS08490 WP_001830374.1 1761339..1762385(-) (vraS) [Staphylococcus epidermidis strain UMCG386]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92