Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | HWI61_RS13260 | Genome accession | NZ_CP064467 |
| Coordinates | 2684324..2685670 (+) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus epidermidis strain UMCG389 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2650518..2705248 | 2684324..2685670 | within | 0 |
Gene organization within MGE regions
Location: 2650518..2705248
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI61_RS13080 (HWI61_12965) | - | 2650518..2651330 (-) | 813 | WP_002504699.1 | abortive infection system antitoxin AbiGi family protein | - |
| HWI61_RS13085 (HWI61_12970) | - | 2651521..2653035 (+) | 1515 | WP_002504700.1 | class I SAM-dependent DNA methyltransferase | - |
| HWI61_RS13090 (HWI61_12975) | - | 2653025..2654299 (+) | 1275 | WP_002504701.1 | restriction endonuclease subunit S | - |
| HWI61_RS13095 (HWI61_12980) | - | 2654283..2657402 (+) | 3120 | WP_002504702.1 | type I restriction endonuclease subunit R | - |
| HWI61_RS13100 (HWI61_12985) | - | 2657480..2657803 (-) | 324 | WP_001176049.1 | PepSY domain-containing protein | - |
| HWI61_RS13105 (HWI61_12990) | - | 2658197..2658418 (-) | 222 | WP_002504703.1 | hypothetical protein | - |
| HWI61_RS13110 (HWI61_12995) | - | 2658367..2658810 (-) | 444 | WP_000941333.1 | hypothetical protein | - |
| HWI61_RS13115 (HWI61_13000) | - | 2658872..2659399 (-) | 528 | WP_002504704.1 | hypothetical protein | - |
| HWI61_RS13120 (HWI61_13005) | - | 2659534..2660022 (-) | 489 | WP_000393586.1 | hypothetical protein | - |
| HWI61_RS13125 (HWI61_13010) | - | 2660038..2660328 (-) | 291 | WP_000065261.1 | hypothetical protein | - |
| HWI61_RS13130 (HWI61_13015) | - | 2660385..2661257 (-) | 873 | WP_000373149.1 | HTH domain-containing protein | - |
| HWI61_RS13135 (HWI61_13020) | - | 2661427..2661873 (-) | 447 | WP_002504705.1 | RadC family protein | - |
| HWI61_RS13140 (HWI61_13025) | - | 2661894..2662400 (-) | 507 | WP_000849085.1 | DUF1643 domain-containing protein | - |
| HWI61_RS13145 (HWI61_13030) | - | 2662416..2662727 (-) | 312 | WP_001083108.1 | DUF960 family protein | - |
| HWI61_RS13150 (HWI61_13035) | - | 2662823..2663161 (-) | 339 | WP_000171557.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI61_RS13155 (HWI61_13040) | ccrC | 2663267..2664943 (-) | 1677 | WP_002504707.1 | cassette chromosome recombinase CcrC | - |
| HWI61_RS13160 (HWI61_13045) | - | 2665168..2666811 (-) | 1644 | WP_002504708.1 | DUF5906 domain-containing protein | - |
| HWI61_RS13165 (HWI61_13050) | - | 2666808..2667179 (-) | 372 | WP_002437511.1 | hypothetical protein | - |
| HWI61_RS13170 (HWI61_13055) | - | 2667172..2668281 (-) | 1110 | WP_002437509.1 | DNA polymerase | - |
| HWI61_RS13175 (HWI61_13060) | - | 2668451..2670463 (-) | 2013 | WP_012088687.1 | hypothetical protein | - |
| HWI61_RS13180 (HWI61_13065) | - | 2670625..2671554 (-) | 930 | WP_002504713.1 | YafY family protein | - |
| HWI61_RS13185 (HWI61_13070) | - | 2671635..2672063 (+) | 429 | WP_000671997.1 | VOC family protein | - |
| HWI61_RS13190 (HWI61_13075) | - | 2672123..2672797 (-) | 675 | Protein_2556 | IS6 family transposase | - |
| HWI61_RS13195 (HWI61_13080) | - | 2673008..2674198 (+) | 1191 | WP_000716034.1 | YbfB/YjiJ family MFS transporter | - |
| HWI61_RS13200 (HWI61_13085) | - | 2674185..2675051 (+) | 867 | WP_002504710.1 | LysR family transcriptional regulator | - |
| HWI61_RS13205 (HWI61_13090) | - | 2675064..2676134 (+) | 1071 | WP_001054882.1 | nitronate monooxygenase family protein | - |
| HWI61_RS13210 (HWI61_13095) | - | 2676299..2676658 (+) | 360 | WP_000432280.1 | DUF4870 domain-containing protein | - |
| HWI61_RS13215 (HWI61_13100) | - | 2676896..2677669 (-) | 774 | WP_000998885.1 | hypothetical protein | - |
| HWI61_RS13220 (HWI61_13105) | - | 2677986..2678150 (-) | 165 | WP_001028954.1 | hypothetical protein | - |
| HWI61_RS13225 (HWI61_13110) | - | 2678355..2679188 (-) | 834 | WP_000694291.1 | CPBP family intramembrane glutamic endopeptidase | - |
| HWI61_RS13230 (HWI61_13115) | - | 2679225..2679551 (-) | 327 | WP_000624048.1 | helix-turn-helix domain-containing protein | - |
| HWI61_RS13235 (HWI61_13120) | - | 2679883..2680455 (-) | 573 | WP_000489177.1 | ADP-ribosyltransferase | - |
| HWI61_RS13240 (HWI61_13125) | - | 2680508..2681557 (-) | 1050 | WP_000613217.1 | hypothetical protein | - |
| HWI61_RS13245 (HWI61_13130) | ssb | 2681695..2681979 (+) | 285 | WP_000659554.1 | cassette chromosome ssDNA-binding protein | - |
| HWI61_RS13250 (HWI61_13135) | cch1 | 2681979..2683766 (+) | 1788 | WP_000181743.1 | cassette chromosome replicative helicase | - |
| HWI61_RS13255 (HWI61_13140) | - | 2683856..2684131 (+) | 276 | WP_001791132.1 | hypothetical protein | - |
| HWI61_RS13260 (HWI61_13145) | ccrA | 2684324..2685670 (+) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
| HWI61_RS13265 (HWI61_13150) | ccrB | 2685691..2687319 (+) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| HWI61_RS13270 (HWI61_13155) | - | 2687790..2688140 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI61_RS13275 (HWI61_13160) | - | 2688225..2688536 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| HWI61_RS13280 (HWI61_13165) | - | 2688555..2689076 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| HWI61_RS13285 (HWI61_13170) | - | 2689078..2689284 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| HWI61_RS13290 (HWI61_13175) | - | 2689277..2689600 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| HWI61_RS13295 (HWI61_13180) | - | 2689795..2691687 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| HWI61_RS13300 (HWI61_13185) | - | 2691694..2692071 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| HWI61_RS13305 (HWI61_13190) | - | 2692309..2692674 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| HWI61_RS13310 (HWI61_13195) | cadA | 2692667..2694847 (+) | 2181 | WP_053038472.1 | cadmium-translocating P-type ATPase CadA | - |
| HWI61_RS13315 (HWI61_13200) | - | 2694928..2695544 (+) | 617 | Protein_2581 | CadD family cadmium resistance transporter | - |
| HWI61_RS13320 (HWI61_13210) | - | 2695818..2696456 (-) | 639 | Protein_2582 | sulfite exporter TauE/SafE family protein | - |
| HWI61_RS13325 (HWI61_13215) | cstR | 2696456..2696716 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| HWI61_RS13330 (HWI61_13220) | - | 2696852..2697916 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| HWI61_RS13335 (HWI61_13225) | cstB | 2697949..2699283 (+) | 1335 | Protein_2585 | persulfide dioxygenase-sulfurtransferase CstB | - |
| HWI61_RS13340 (HWI61_13230) | - | 2699397..2700527 (-) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| HWI61_RS13345 (HWI61_13235) | psm-mec | 2700861..2700929 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| HWI61_RS13350 (HWI61_13240) | mecI | 2701014..2701385 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| HWI61_RS13355 (HWI61_13245) | mecR1 | 2701385..2703142 (-) | 1758 | WP_002504642.1 | beta-lactam sensor/signal transducer MecR1 | - |
| HWI61_RS13360 (HWI61_13250) | mecA | 2703239..2705248 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=502143 HWI61_RS13260 WP_000816499.1 2684324..2685670(+) (ccrA) [Staphylococcus epidermidis strain UMCG389]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=502143 HWI61_RS13260 WP_000816499.1 2684324..2685670(+) (ccrA) [Staphylococcus epidermidis strain UMCG389]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |