Detailed information NTG0502135

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI61_RS08270
• Genome accession: NZ_CP064467
• Coordinates: 1665773..1666819 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG389
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1660773..1671819

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI61_RS08240 (HWI61_08155)	-	1661157..1662398 (-)	1242	WP_001832467.1	aminopeptidase	-
HWI61_RS08245 (HWI61_08160)	-	1662400..1662615 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI61_RS08250 (HWI61_08165)	-	1662756..1663220 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI61_RS08255 (HWI61_08170)	-	1663228..1663512 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI61_RS08260 (HWI61_08175)	-	1663919..1665097 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI61_RS08265 (HWI61_08180)	vraR	1665154..1665783 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI61_RS08270 (HWI61_08185)	vraS	1665773..1666819 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI61_RS08275 (HWI61_08190)	liaF	1666816..1667517 (-)	702	WP_063964223.1	cell wall-active antibiotics response protein LiaF	-
HWI61_RS08280 (HWI61_08195)	-	1667532..1667918 (-)	387	WP_001830382.1	hypothetical protein	-
HWI61_RS08285 (HWI61_08200)	map	1668076..1668831 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI61_RS08290 (HWI61_08205)	-	1669005..1669991 (+)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI61_RS08295 (HWI61_08210)	isaB	1670142..1670678 (-)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=502135 HWI61_RS08270 WP_001830374.1 1665773..1666819(-) (vraS) [Staphylococcus epidermidis strain UMCG389]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=502135 HWI61_RS08270 WP_001830374.1 1665773..1666819(-) (vraS) [Staphylococcus epidermidis strain UMCG389]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92