Detailed information NTG0502045

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI63_RS04595
• Genome accession: NZ_CP064461
• Coordinates: 974223..975269 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG391
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 969223..980269

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI63_RS04570 (HWI63_04525)	isaB	970364..970900 (+)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-
HWI63_RS04575 (HWI63_04530)	-	971051..972037 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI63_RS04580 (HWI63_04535)	map	972211..972966 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI63_RS04585 (HWI63_04540)	-	973124..973510 (+)	387	WP_001830382.1	hypothetical protein	-
HWI63_RS04590 (HWI63_04545)	liaF	973525..974226 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
HWI63_RS04595 (HWI63_04550)	vraS	974223..975269 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI63_RS04600 (HWI63_04555)	vraR	975259..975888 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI63_RS04605 (HWI63_04560)	-	975945..977123 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI63_RS04610 (HWI63_04565)	-	977530..977814 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI63_RS04615 (HWI63_04570)	-	977822..978286 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI63_RS04620 (HWI63_04575)	-	978427..978642 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI63_RS04625 (HWI63_04580)	-	978644..979885 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=502045 HWI63_RS04595 WP_001830374.1 974223..975269(+) (vraS) [Staphylococcus epidermidis strain UMCG391]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=502045 HWI63_RS04595 WP_001830374.1 974223..975269(+) (vraS) [Staphylococcus epidermidis strain UMCG391]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92