Detailed information NTG0501073

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: IUJ46_RS05300
• Genome accession: NZ_CP064364
• Coordinates: 1014912..1015949 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain PartK-Spyogenes-RM8376
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1009912..1020949

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IUJ46_RS05280 (IUJ46_05255)	-	1010662..1011288 (+)	627	WP_010922497.1	A24 family peptidase	-
IUJ46_RS05285 (IUJ46_05260)	rlmN	1011370..1012449 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
IUJ46_RS05290 (IUJ46_05265)	-	1012453..1013073 (-)	621	WP_011285637.1	YutD family protein	-
IUJ46_RS05295 (IUJ46_05270)	-	1013521..1014498 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
IUJ46_RS05300 (IUJ46_05275)	sepM	1014912..1015949 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
IUJ46_RS05305 (IUJ46_05280)	coaD	1015936..1016427 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
IUJ46_RS05310 (IUJ46_05285)	rsmD	1016417..1016956 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
IUJ46_RS05315 (IUJ46_05290)	asnA	1017079..1018071 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
IUJ46_RS05320 (IUJ46_05295)	arcC	1018384..1019334 (-)	951	WP_010922501.1	carbamate kinase	-
IUJ46_RS05325 (IUJ46_05300)	-	1019354..1020685 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=501073 IUJ46_RS05300 WP_010922499.1 1014912..1015949(-) (sepM) [Streptococcus pyogenes strain PartK-Spyogenes-RM8376]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=501073 IUJ46_RS05300 WP_010922499.1 1014912..1015949(-) (sepM) [Streptococcus pyogenes strain PartK-Spyogenes-RM8376]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693