Detailed information NTG0049777

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: SSUD12_RS02475
• Genome accession: NC_017621
• Coordinates: 478923..481151 (-)
• Length: 742 a.a.
• NCBI ID: WP_014637570.1
• Uniprot ID: G7SDM6
• Organism: Streptococcus suis D12
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 473923..486151

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SSUD12_RS02455 (SSUD12_0461)	-	474487..474930 (+)	444	WP_014637568.1	GNAT family N-acetyltransferase	-
SSUD12_RS02460 (SSUD12_0462)	ileS	474941..477730 (+)	2790	WP_014637569.1	isoleucine--tRNA ligase	-
SSUD12_RS02465 (SSUD12_0463)	-	477913..478221 (-)	309	WP_002938710.1	DUF1827 family protein	-
SSUD12_RS02470 (SSUD12_0464)	-	478276..478737 (-)	462	WP_002938708.1	NUDIX hydrolase	-
SSUD12_RS02475 (SSUD12_0465)	clpE	478923..481151 (-)	2229	WP_014637570.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
SSUD12_RS02480 (SSUD12_0466)	-	481375..481605 (+)	231	WP_002938704.1	DUF1797 family protein	-
SSUD12_RS02485 (SSUD12_0467)	-	481731..482420 (+)	690	WP_002938702.1	amino acid ABC transporter permease	-
SSUD12_RS02490 (SSUD12_0468)	-	482413..483147 (+)	735	WP_014637571.1	amino acid ABC transporter ATP-binding protein	-
SSUD12_RS02495 (SSUD12_0469)	-	483381..484229 (+)	849	WP_014637572.1	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	-
SSUD12_RS02500 (SSUD12_0470)	-	485658..485957 (+)	300	WP_014637573.1	hypothetical protein	-

Sequence

Protein

• Length: 742 a.a.
• Molecular weight: 82666.06 Da
• Isoelectric Point: 5.3518

>NTDB_id=49777 SSUD12_RS02475 WP_014637570.1 478923..481151(-) (clpE) [Streptococcus suis D12]
MLCKNCNINDATIHLYTNLNGKQQQVDLCHNCYQIMKTDPNNAILRGLGDLTNPNNMDPFSEFFNHLGGYPGNTPAGKNR
EQTPPTQAGGHNGRGGQTPPPQQPQQPNGLLEEFGINVTEIARRGDIDPVIGRDQEITRVIEILNRRTKNNPVLIGEPGV
GKTAVVEGLAQKIVDGDVPQKLRDKEVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRREIILFIDEIHEIVGAGSAGD
GNMDAGNILKPALARGEMQLVGATTLNEYRIIEKDAALERRMQPVKVEEPSVEETITILKGIQNKYQDYHHVKYSDAAIE
AAAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFIDPKEIDQRLIDAENRKAQATRDEDYEKAAYFRDQIAKYKEMQK
ATISEEDIPLITEKEIEAIVEQKTNIPVGDLKEKEQSQLVNLASDLKAHVIGQDEAVDKIAKAIRRNRVGLGAPNRPIGS
FLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILLDEVE
KAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAAMEGRTQSVLGQLSNFFTPEFMNRFDG
IIEFQPLSKENLLEIVSLMLDDVNKRLSHNGIRLHVTDKVKEKLVDLGYDPKMGARPLRRTIQDQIEDAITDFYLEHPAE
KDLRAVMSSKGTIQIKAQTKTK

Nucleotide

• Length: 2229 bp

>NTDB_id=49777 SSUD12_RS02475 WP_014637570.1 478923..481151(-) (clpE) [Streptococcus suis D12]
ATGCTCTGCAAAAATTGTAATATCAACGACGCAACGATCCATCTCTACACCAACTTAAACGGTAAACAGCAGCAGGTAGA
CCTCTGTCACAACTGCTACCAAATCATGAAAACAGACCCTAATAATGCCATCCTACGTGGGTTGGGAGATTTAACAAATC
CTAACAATATGGATCCCTTTAGTGAATTCTTCAATCACCTAGGTGGCTATCCTGGCAATACCCCTGCTGGAAAAAATCGC
GAACAGACTCCTCCCACTCAAGCCGGTGGGCATAATGGACGTGGTGGACAGACCCCTCCTCCGCAACAACCTCAACAACC
AAATGGGCTCCTTGAAGAATTTGGTATCAACGTTACCGAAATTGCCCGTCGTGGGGATATTGATCCAGTAATCGGTCGCG
ATCAAGAGATTACCCGTGTCATCGAAATTCTCAACCGTCGTACAAAAAACAACCCTGTTCTTATCGGTGAGCCTGGTGTA
GGTAAAACAGCAGTTGTTGAAGGCTTGGCTCAAAAAATTGTCGATGGCGATGTCCCACAGAAATTACGAGACAAGGAAGT
CATTCGTCTGGATGTTGTCAGCCTCGTACAAGGAACAGGTATCCGCGGACAATTTGAAGAACGCATGCAAAAACTCATGG
AAGAAATCCGTAATCGTCGCGAAATTATTCTTTTTATTGACGAGATTCACGAAATTGTCGGTGCTGGCTCTGCAGGCGAT
GGTAACATGGATGCAGGCAATATCCTCAAACCAGCCCTCGCACGTGGTGAAATGCAACTAGTCGGTGCAACAACGCTCAA
CGAGTACCGTATTATCGAAAAAGATGCCGCCCTAGAACGCCGTATGCAACCTGTAAAAGTTGAAGAACCAAGTGTCGAAG
AAACCATTACTATTCTCAAAGGTATCCAAAATAAATACCAGGATTACCATCATGTTAAATACTCCGATGCTGCTATCGAA
GCTGCCGCAGTACTGTCCAACCGCTACATTCAAGACCGTTTCCTACCAGACAAAGCTATTGACCTTCTGGATGAAGCTGG
TTCAAAAATGAATTTGACCCTCAACTTTATTGATCCAAAGGAAATTGACCAACGCCTGATTGATGCCGAAAATCGGAAAG
CACAAGCTACACGGGATGAGGACTATGAAAAAGCAGCCTATTTCCGTGACCAAATTGCTAAGTACAAGGAGATGCAAAAG
GCAACTATCAGCGAGGAAGATATTCCACTCATTACTGAAAAAGAAATTGAGGCCATCGTTGAGCAAAAAACAAATATCCC
AGTTGGTGATTTAAAAGAAAAGGAACAGTCCCAGCTTGTGAACCTCGCTAGTGACTTAAAAGCCCATGTTATCGGACAAG
ATGAAGCAGTTGACAAGATAGCTAAAGCCATCCGCCGTAATCGTGTCGGTCTCGGTGCTCCAAATCGTCCCATTGGATCC
TTCCTCTTTGTCGGACCAACAGGTGTCGGTAAAACCGAATTGTCTAAGCAATTAGCTATCGAACTCTTCGGTTCGGCTGA
CAGCATGATCCGCTTCGACATGTCCGAATATATGGAGAAACACGCCGTAGCCAAACTGGTCGGTGCCCCTCCAGGTTATG
TAGGCTACGAGGAAGCCGGTCAGCTAACTGAAAAAGTCCGTCGTAATCCTTACTCACTCATCCTCCTTGACGAAGTTGAA
AAAGCCCACCCAGATGTCATGCACATGTTCCTTCAGGTCTTAGACGATGGGCGTCTGACAGATGGACAAGGGCGGACAGT
CAGCTTCAAAGATACCATTATCATCATGACATCAAATGCTGGTACTGGAAAAGTTGAAGCAAGTGTCGGTTTTGGTGCGG
CTATGGAAGGGCGGACTCAATCAGTCCTTGGCCAACTTAGCAATTTCTTCACACCTGAATTTATGAACCGATTTGACGGT
ATTATTGAGTTCCAACCACTGAGCAAGGAAAACCTACTTGAAATCGTCAGCCTCATGCTAGACGATGTAAACAAACGCCT
TTCTCACAATGGCATCCGCCTCCATGTAACAGATAAAGTTAAGGAGAAATTAGTGGACCTTGGCTACGATCCAAAGATGG
GAGCTCGTCCACTACGCAGAACCATCCAAGATCAGATTGAAGATGCTATCACCGACTTCTACTTAGAACATCCAGCAGAA
AAAGACCTACGTGCTGTCATGTCAAGTAAAGGTACAATTCAAATCAAGGCACAAACAAAGACAAAATAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (476-639)

• AAA lid domain (AAA_lid_9) (291-389)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (647-721)

• ATPase family associated with various cellular activities (AAA) (AAA) (153-272)

3D structure

• AlphaFold DB: G7SDM6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus pneumoniae Rx1	82.493	100	0.838
clpE	Streptococcus pneumoniae D39	82.493	100	0.838
clpE	Streptococcus pneumoniae R6	82.493	100	0.838
clpE	Streptococcus pneumoniae TIGR4	82.493	100	0.838
clpE	Streptococcus mutans UA159	82.377	100	0.832
clpC	Lactococcus lactis subsp. cremoris KW2	77.655	97.709	0.759
clpC	Bacillus subtilis subsp. subtilis str. 168	52.308	87.601	0.458
clpC	Streptococcus mutans UA159	48.558	84.097	0.408
clpC	Streptococcus thermophilus LMD-9	48.089	84.636	0.407
clpC	Streptococcus thermophilus LMG 18311	47.771	84.636	0.404
clpC	Streptococcus pneumoniae TIGR4	47.84	84.232	0.403
clpC	Streptococcus pneumoniae Rx1	47.84	84.232	0.403
clpC	Streptococcus pneumoniae D39	47.84	84.232	0.403
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46.815	84.636	0.396