Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   IRE31_RS02690 Genome accession   NZ_CP063829
Coordinates   511808..512545 (+) Length   245 a.a.
NCBI ID   WP_001219126.1    Uniprot ID   A7XHJ0
Organism   Streptococcus pneumoniae strain 19A-ST320_99-176     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 506808..517545
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IRE31_RS02655 (IRE31_02625) - 507784..507978 (-) 195 WP_001808905.1 hypothetical protein -
  IRE31_RS02660 (IRE31_02630) - 508140..508427 (-) 288 WP_000777760.1 hypothetical protein -
  IRE31_RS02665 (IRE31_02635) - 508437..508847 (-) 411 WP_001278301.1 HIT family protein -
  IRE31_RS02670 (IRE31_02640) pptA 508915..509646 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  IRE31_RS02675 (IRE31_02645) - 509643..510692 (+) 1050 WP_000653752.1 ABC transporter permease -
  IRE31_RS02680 (IRE31_02650) - 510860..511189 (-) 330 WP_000132575.1 hypothetical protein -
  IRE31_RS02685 (IRE31_02655) - 511465..511803 (+) 339 WP_000682122.1 LytTR family DNA-binding domain-containing protein -
  IRE31_RS02690 (IRE31_02660) comE/blpR 511808..512545 (+) 738 WP_001219126.1 response regulator transcription factor Regulator
  IRE31_RS02695 (IRE31_02665) - 512558..513898 (+) 1341 WP_000275284.1 sensor histidine kinase -
  IRE31_RS02700 (IRE31_02670) - 514138..515484 (-) 1347 WP_001821303.1 IS1380-like element ISSpn5 family transposase -
  IRE31_RS02705 (IRE31_02675) blpC 515651..515806 (-) 156 WP_000358814.1 quorum-sensing system pheromone BlpC -
  IRE31_RS02710 (IRE31_02680) - 515863..517224 (-) 1362 WP_001069099.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28752.92 Da        Isoelectric Point: 6.2357

>NTDB_id=496894 IRE31_RS02690 WP_001219126.1 511808..512545(+) (comE/blpR) [Streptococcus pneumoniae strain 19A-ST320_99-176]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=496894 IRE31_RS02690 WP_001219126.1 511808..512545(+) (comE/blpR) [Streptococcus pneumoniae strain 19A-ST320_99-176]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A7XHJ0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.909

99.184

0.535
  comE/comE1 Streptococcus equinus JB1

43.882

96.735

0.424
  comE/comE2 Streptococcus equinus JB1

38.843

98.776

0.384