Detailed information NTG0049679

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: SSU12_RS02435
• Genome accession: NC_017619
• Coordinates: 480919..483147 (-)
• Length: 742 a.a.
• NCBI ID: WP_011922698.1
• Uniprot ID: D5AGE0
• Organism: Streptococcus suis SS12
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 475919..488147

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SSU12_RS02415 (SSU12_0449)	-	476287..476730 (+)	444	WP_012774999.1	GNAT family N-acetyltransferase	-
SSU12_RS02420 (SSU12_0450)	ileS	476741..479530 (+)	2790	WP_012775000.1	isoleucine--tRNA ligase	-
SSU12_RS02425 (SSU12_0451)	-	479909..480217 (-)	309	WP_002938710.1	DUF1827 family protein	-
SSU12_RS02430 (SSU12_0452)	-	480272..480733 (-)	462	WP_002938708.1	NUDIX hydrolase	-
SSU12_RS02435 (SSU12_0453)	clpE	480919..483147 (-)	2229	WP_011922698.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
SSU12_RS02440 (SSU12_0454)	-	483371..483601 (+)	231	WP_002938704.1	DUF1797 family protein	-
SSU12_RS02445 (SSU12_0455)	-	483727..484416 (+)	690	WP_002938702.1	amino acid ABC transporter permease	-
SSU12_RS02450 (SSU12_0456)	-	484409..485143 (+)	735	WP_002943067.1	amino acid ABC transporter ATP-binding protein	-
SSU12_RS02455 (SSU12_0457)	-	485273..486121 (+)	849	WP_011922050.1	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	-
SSU12_RS02460 (SSU12_0458)	-	487570..487863 (+)	294	WP_002938694.1	hypothetical protein	-

Sequence

Protein

• Length: 742 a.a.
• Molecular weight: 82607.98 Da
• Isoelectric Point: 5.4248

>NTDB_id=49679 SSU12_RS02435 WP_011922698.1 480919..483147(-) (clpE) [Streptococcus suis SS12]
MLCKNCNINDATIHLYTNLNGKQQQVDLCHNCYQIMKTDPHNAILRGLGDLTNPNNMDPFSEFFNHLGGYPGNTPAGKNR
EQTPPTQAGGHNGRGGQTPPPQQPQQPNGLLEEFGINVTEIARRGDIDPVIGRDQEITRVIEILNRRTKNNPVLIGEPGV
GKTAVVEGLAQKIVDGDVPQKLRDKEVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRREIILFIDEIHEIVGAGSAGD
GNMDAGNILKPALARGEMQLVGATTLNEYRIIEKDAALERRMQPVKVEEPSVEETITILKGIQNKYQDYHHVKYSDAAIE
AAAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFIDPKEIDQRLIDSENRKAQATRDEDYEKAAYFRDQIAKYKEMQK
ATISEEDIPLITEKEIEAIVEQKTNIPVGDLKEKEQSQLVSLASDLKAHVIGQDEAVDKIAKAIRRNRVGLGAPNRPIGS
FLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILLDEVE
KAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAAMEGRTQSVLGQLSNFFTPEFMNRFDG
IIEFQPLSKENLLEIVSLMLDDVNKRLSHNGISLHVTDKVKEKLVDLGYNPKMGARPLRRTIQDQIEDAITDFYLEHPAE
KDLRAVMSSKGTIQIKAQTKTK

Nucleotide

• Length: 2229 bp

>NTDB_id=49679 SSU12_RS02435 WP_011922698.1 480919..483147(-) (clpE) [Streptococcus suis SS12]
ATGCTCTGCAAAAATTGTAATATCAACGACGCAACGATCCATCTCTACACCAACTTAAACGGTAAACAGCAGCAGGTAGA
CCTCTGTCACAACTGCTACCAAATCATGAAAACAGACCCTCATAATGCTATCCTACGTGGGTTGGGAGATTTAACAAATC
CTAACAATATGGATCCCTTTAGTGAATTTTTCAATCACCTAGGTGGCTATCCTGGCAATACCCCTGCTGGAAAAAATCGC
GAACAGACTCCTCCCACTCAAGCCGGTGGGCATAATGGACGTGGTGGACAGACCCCTCCTCCGCAACAACCCCAACAACC
AAATGGGCTCCTTGAAGAATTTGGTATCAACGTTACCGAAATTGCCCGTCGTGGGGATATTGATCCAGTAATCGGTCGCG
ATCAAGAAATTACCCGTGTCATCGAAATTCTCAACCGTCGTACAAAAAACAATCCTGTTCTTATCGGTGAGCCTGGGGTA
GGTAAAACAGCGGTTGTTGAAGGCTTGGCTCAAAAAATTGTCGATGGCGATGTCCCACAAAAATTACGAGACAAGGAAGT
CATTCGTCTGGATGTTGTCAGCCTCGTACAAGGAACAGGTATCCGTGGACAATTTGAAGAACGCATGCAAAAACTCATGG
AAGAAATCCGTAATCGTCGCGAAATCATTCTTTTTATTGACGAGATTCACGAAATTGTCGGTGCTGGCTCTGCAGGCGAT
GGTAACATGGATGCAGGCAATATCCTCAAACCAGCCCTCGCACGTGGTGAAATGCAACTAGTCGGTGCAACAACGCTCAA
CGAGTACCGTATTATCGAAAAAGATGCCGCCCTAGAACGCCGTATGCAACCTGTAAAAGTTGAAGAACCAAGTGTCGAAG
AAACCATTACCATCCTCAAAGGTATCCAAAATAAATACCAGGATTACCATCATGTTAAATACTCCGATGCTGCTATCGAA
GCTGCCGCAGTACTGTCCAATCGCTACATTCAAGACCGTTTCCTACCAGACAAGGCTATTGACCTTCTGGATGAAGCTGG
TTCAAAAATGAATTTGACCCTCAACTTTATTGATCCAAAGGAAATTGACCAACGCCTGATTGATTCCGAAAATCGTAAAG
CACAAGCTACACGGGATGAGGACTATGAAAAAGCAGCCTATTTCCGTGACCAAATTGCTAAGTACAAGGAGATGCAAAAG
GCAACTATCAGCGAAGAAGATATTCCACTCATTACTGAAAAAGAAATTGAAGCCATCGTTGAGCAAAAAACAAATATCCC
AGTTGGTGATTTAAAAGAAAAGGAACAGTCCCAGCTTGTGAGCCTCGCTAGTGACTTAAAAGCCCATGTTATCGGACAAG
ATGAAGCAGTTGACAAGATAGCTAAAGCCATCCGCCGTAATCGTGTCGGTCTCGGTGCTCCAAATCGTCCCATTGGTTCC
TTCCTCTTTGTCGGACCAACAGGTGTCGGTAAAACCGAATTGTCTAAGCAATTAGCTATCGAACTCTTCGGTTCGGCTGA
CAGCATGATCCGCTTCGACATGTCCGAATACATGGAAAAACACGCTGTCGCTAAACTCGTCGGAGCTCCTCCAGGCTATG
TAGGCTATGAGGAGGCTGGACAATTGACTGAAAAAGTTCGTCGTAATCCTTACTCACTCATCCTCCTTGACGAAGTTGAA
AAAGCCCACCCAGATGTCATGCACATGTTCCTTCAGGTCTTAGATGATGGGCGTCTGACAGATGGACAAGGTCGGACAGT
CAGCTTCAAAGATACCATTATCATCATGACATCAAATGCTGGTACTGGAAAAGTTGAAGCAAGTGTCGGTTTTGGTGCGG
CTATGGAAGGGCGGACTCAATCAGTCCTTGGCCAACTTAGCAATTTCTTCACACCTGAATTTATGAACCGATTTGACGGT
ATTATTGAGTTCCAACCACTGAGCAAGGAAAACCTACTTGAAATCGTCAGCCTCATGCTAGACGATGTAAACAAACGCCT
TTCTCACAATGGCATCAGCCTCCATGTAACAGATAAAGTTAAGGAGAAATTAGTGGACCTTGGCTACAATCCAAAGATGG
GAGCTCGTCCACTACGCAGAACCATCCAAGATCAGATTGAAGATGCTATCACCGACTTCTACTTAGAACATCCAGCAGAA
AAAGACCTACGTGCTGTCATGTCAAGTAAAGGTACAATTCAAATCAAGGCACAAACAAAGACAAAATAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (291-388)

• AAA domain (Cdc48 subfamily) (AAA_2) (476-639)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (647-721)

• ATPase family associated with various cellular activities (AAA) (AAA) (153-272)

3D structure

• AlphaFold DB: D5AGE0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus pneumoniae Rx1	81.963	100	0.833
clpE	Streptococcus pneumoniae D39	81.963	100	0.833
clpE	Streptococcus pneumoniae R6	81.963	100	0.833
clpE	Streptococcus pneumoniae TIGR4	81.963	100	0.833
clpE	Streptococcus mutans UA159	82.109	100	0.829
clpC	Lactococcus lactis subsp. cremoris KW2	77.517	97.709	0.757
clpC	Bacillus subtilis subsp. subtilis str. 168	52.154	87.601	0.457
clpC	Streptococcus thermophilus LMD-9	47.93	84.636	0.406
clpC	Streptococcus mutans UA159	48.237	84.097	0.406
clpC	Streptococcus thermophilus LMG 18311	47.611	84.636	0.403
clpC	Streptococcus pneumoniae Rx1	47.52	84.232	0.4
clpC	Streptococcus pneumoniae D39	47.52	84.232	0.4
clpC	Streptococcus pneumoniae TIGR4	47.52	84.232	0.4
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46.338	84.636	0.392