Detailed information NTG0496408

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF732_RS00495
• Genome accession: NZ_CP063745
• Coordinates: 92108..93151 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_212
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 87108..98151

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF732_RS00465 (IF732_00460)	-	87833..87943 (+)	111	WP_014937049.1	hypothetical protein	-
IF732_RS00470 (IF732_00465)	-	87972..88385 (+)	414	WP_025174370.1	hypothetical protein	-
IF732_RS00475 (IF732_00470)	-	88574..89560 (-)	987	WP_000999712.1	aromatic acid exporter family protein	-
IF732_RS00480 (IF732_00475)	map	90034..90792 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
IF732_RS00485 (IF732_00480)	-	91009..91395 (+)	387	WP_001110182.1	hypothetical protein	-
IF732_RS00490 (IF732_00485)	liaF	91410..92111 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF732_RS00495 (IF732_00490)	vraS	92108..93151 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF732_RS00500 (IF732_00495)	vraR	93141..93770 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
IF732_RS00505 (IF732_00500)	-	93883..95100 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
IF732_RS00510 (IF732_00505)	-	95378..95653 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF732_RS00515 (IF732_00510)	-	95660..96124 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF732_RS00520 (IF732_00515)	-	96271..96471 (+)	201	WP_000180460.1	DUF1128 family protein	-
IF732_RS00525 (IF732_00520)	-	96474..97730 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=496408 IF732_RS00495 WP_001017131.1 92108..93151(+) (vraS) [Staphylococcus aureus strain NAS_AN_212]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=496408 IF732_RS00495 WP_001017131.1 92108..93151(+) (vraS) [Staphylococcus aureus strain NAS_AN_212]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1