Detailed information NTG0493296

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IMZ86_RS04965
• Genome accession: NZ_CP063143
• Coordinates: 1074306..1075349 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain IVK28
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1069306..1080349

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IMZ86_RS04940 (IMZ86_04940)	-	1069596..1070957 (-)	1362	WP_037540479.1	FAD-dependent oxidoreductase	-
IMZ86_RS04945 (IMZ86_04945)	-	1071091..1072071 (-)	981	WP_002492696.1	FUSC family protein	-
IMZ86_RS04950 (IMZ86_04950)	map	1072316..1073071 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
IMZ86_RS04955 (IMZ86_04955)	-	1073197..1073583 (+)	387	WP_002477960.1	hypothetical protein	-
IMZ86_RS04960 (IMZ86_04960)	liaF	1073608..1074309 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
IMZ86_RS04965 (IMZ86_04965)	vraS	1074306..1075349 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
IMZ86_RS04970 (IMZ86_04970)	vraR	1075339..1075968 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
IMZ86_RS04975 (IMZ86_04975)	-	1076141..1077370 (-)	1230	WP_002492699.1	YihY/virulence factor BrkB family protein	-
IMZ86_RS04980 (IMZ86_04980)	-	1077573..1077857 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
IMZ86_RS04985 (IMZ86_04985)	-	1077864..1078328 (-)	465	WP_002492719.1	low molecular weight protein-tyrosine-phosphatase	-
IMZ86_RS04990 (IMZ86_04990)	-	1078492..1078677 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
IMZ86_RS04995 (IMZ86_04995)	-	1078690..1079928 (+)	1239	WP_002461326.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=493296 IMZ86_RS04965 WP_002461334.1 1074306..1075349(+) (vraS) [Staphylococcus lugdunensis strain IVK28]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=493296 IMZ86_RS04965 WP_002461334.1 1074306..1075349(+) (vraS) [Staphylococcus lugdunensis strain IVK28]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911