Detailed information NTG0049329

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: SPNINV200_RS08700
• Genome accession: NC_017593
• Coordinates: 1664411..1665070 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565010.1
• Uniprot ID: A0A0B7M2C6
• Organism: Streptococcus pneumoniae INV200
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1659411..1670070

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPNINV200_RS08675 (SPNINV200_16300)	-	1659716..1660033 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
SPNINV200_RS08680 (SPNINV200_16310)	-	1660048..1660944 (-)	897	WP_000825669.1	PEP phosphonomutase	-
SPNINV200_RS08685 (SPNINV200_16320)	-	1660947..1662209 (-)	1263	WP_000413336.1	PTS sugar transporter subunit IIC	-
SPNINV200_RS08690 (SPNINV200_16330)	-	1662489..1663667 (+)	1179	WP_000175876.1	ROK family transcriptional regulator	-
SPNINV200_RS08695 (SPNINV200_16340)	-	1663943..1664341 (-)	399	WP_000155403.1	GNAT family N-acetyltransferase	-
SPNINV200_RS08700 (SPNINV200_16350)	cclA/cilC	1664411..1665070 (+)	660	WP_000565010.1	prepilin peptidase	Machinery gene
SPNINV200_RS08705 (SPNINV200_16360)	-	1665122..1666273 (-)	1152	WP_000481751.1	helix-turn-helix domain-containing protein	-
SPNINV200_RS08710 (SPNINV200_16370)	-	1666288..1667019 (-)	732	Protein_1646	hypothetical protein	-
SPNINV200_RS12075	-	1667239..1667349 (+)	111	Protein_1647	prepilin peptidase	-
SPNINV200_RS08715 (SPNINV200_16380)	trpA	1667321..1668097 (-)	777	WP_001126993.1	tryptophan synthase subunit alpha	-
SPNINV200_RS08720 (SPNINV200_16390)	trpB	1668090..1669313 (-)	1224	WP_000331298.1	tryptophan synthase subunit beta	-
SPNINV200_RS08725 (SPNINV200_16400)	-	1669291..1669890 (-)	600	WP_000169909.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24845.99 Da
• Isoelectric Point: 7.5762

>NTDB_id=49329 SPNINV200_RS08700 WP_000565010.1 1664411..1665070(+) (cclA/cilC) [Streptococcus pneumoniae INV200]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=49329 SPNINV200_RS08700 WP_000565010.1 1664411..1665070(+) (cclA/cilC) [Streptococcus pneumoniae INV200]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7M2C6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae Rx1	100	100	1
cclA/cilC	Streptococcus pneumoniae D39	100	100	1
cclA/cilC	Streptococcus pneumoniae R6	100	100	1
cclA/cilC	Streptococcus pneumoniae TIGR4	94.977	100	0.95
cclA/cilC	Streptococcus mitis SK321	92.694	100	0.927
cclA/cilC	Streptococcus mitis NCTC 12261	87.671	100	0.877