Detailed information NTG0049187

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: INV104_RS09800
• Genome accession: NC_017591
• Coordinates: 1852742..1853779 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae INV104
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1847742..1858779

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
INV104_RS09775 (INV104_16860)	-	1848481..1849812 (-)	1332	WP_000390043.1	hemolysin family protein	-
INV104_RS09780 (INV104_16870)	endA	1850103..1850927 (-)	825	WP_001036790.1	DNA-entry nuclease EndA	Machinery gene
INV104_RS09785 (INV104_16880)	-	1850966..1851154 (-)	189	WP_001818955.1	DNA-directed RNA polymerase subunit beta	-
INV104_RS09790 (INV104_16890)	murA	1851147..1852430 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
INV104_RS09795 (INV104_16900)	-	1852454..1852684 (-)	231	WP_000250391.1	DUF1146 family protein	-
INV104_RS09800 (INV104_16910)	sepM	1852742..1853779 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
INV104_RS09805 (INV104_16920)	coaD	1853763..1854251 (-)	489	WP_001280723.1	pantetheine-phosphate adenylyltransferase	-
INV104_RS09810 (INV104_16930)	rsmD	1854241..1854780 (-)	540	WP_000706964.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
INV104_RS09815 (INV104_16940)	asnA	1854845..1855837 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
INV104_RS09825 (INV104_16950)	-	1855949..1856632 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
INV104_RS09830 (INV104_16960)	-	1856688..1857428 (-)	741	WP_000152678.1	TrmH family RNA methyltransferase	-
INV104_RS09835 (INV104_16970)	-	1857462..1857740 (+)	279	WP_001174613.1	acylphosphatase	-
INV104_RS09840 (INV104_16980)	yidC	1857818..1858744 (+)	927	WP_000835941.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=49187 INV104_RS09800 WP_000727277.1 1852742..1853779(-) (sepM) [Streptococcus pneumoniae INV104]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=49187 INV104_RS09800 WP_000727277.1 1852742..1853779(-) (sepM) [Streptococcus pneumoniae INV104]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCTACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGGAAGATTATCACCTTGGAAAATGGAAAAAATGGGATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591