Detailed information NTG0490334

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ILP75_RS04255
• Genome accession: NZ_CP062471
• Coordinates: 856976..858019 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain MRSA - AMRF 3
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 851976..863019

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ILP75_RS04225 (ILP75_04225)	-	852398..853654 (-)	1257	WP_075583716.1	aminopeptidase	-
ILP75_RS04230 (ILP75_04230)	-	853657..853857 (-)	201	WP_000180460.1	DUF1128 family protein	-
ILP75_RS04235 (ILP75_04235)	-	854004..854468 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ILP75_RS04240 (ILP75_04240)	-	854475..854750 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ILP75_RS04245 (ILP75_04245)	-	855028..856245 (+)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
ILP75_RS04250 (ILP75_04250)	vraR	856357..856986 (-)	630	WP_000153528.1	two-component system response regulator VraR	Regulator
ILP75_RS04255 (ILP75_04255)	vraS	856976..858019 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ILP75_RS04260 (ILP75_04260)	liaF	858016..858717 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ILP75_RS04265 (ILP75_04265)	-	858732..859118 (-)	387	WP_001110179.1	hypothetical protein	-
ILP75_RS04270 (ILP75_04270)	map	859335..860093 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ILP75_RS04275 (ILP75_04275)	-	860565..861551 (+)	987	WP_000999718.1	FUSC family protein	-
ILP75_RS04280 (ILP75_04280)	-	861982..862395 (-)	414	WP_001837637.1	hypothetical protein	-
ILP75_RS04285 (ILP75_04285)	-	862424..862534 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=490334 ILP75_RS04255 WP_001017131.1 856976..858019(-) (vraS) [Staphylococcus aureus strain MRSA - AMRF 3]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=490334 ILP75_RS04255 WP_001017131.1 856976..858019(-) (vraS) [Staphylococcus aureus strain MRSA - AMRF 3]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1