Detailed information NTG0490238

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ILP77_RS08545
• Genome accession: NZ_CP062467
• Coordinates: 1734614..1735657 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain MRSA - AMRF 5
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1729614..1740657

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ILP77_RS08515 (ILP77_08515)	-	1730099..1730209 (+)	111	WP_001790257.1	hypothetical protein	-
ILP77_RS08520 (ILP77_08520)	-	1730238..1730651 (+)	414	WP_001837637.1	hypothetical protein	-
ILP77_RS08525 (ILP77_08525)	-	1731082..1732068 (-)	987	WP_000999718.1	FUSC family protein	-
ILP77_RS08530 (ILP77_08530)	map	1732540..1733298 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ILP77_RS08535 (ILP77_08535)	-	1733515..1733901 (+)	387	WP_001110179.1	hypothetical protein	-
ILP77_RS08540 (ILP77_08540)	liaF	1733916..1734617 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ILP77_RS08545 (ILP77_08545)	vraS	1734614..1735657 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ILP77_RS08550 (ILP77_08550)	vraR	1735647..1736276 (+)	630	WP_000153528.1	two-component system response regulator VraR	Regulator
ILP77_RS08555 (ILP77_08555)	-	1736388..1737605 (-)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
ILP77_RS08560 (ILP77_08560)	-	1737883..1738158 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ILP77_RS08565 (ILP77_08565)	-	1738165..1738629 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ILP77_RS08570 (ILP77_08570)	-	1738776..1738976 (+)	201	WP_000180460.1	DUF1128 family protein	-
ILP77_RS08575 (ILP77_08575)	-	1738979..1740235 (+)	1257	WP_075583716.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=490238 ILP77_RS08545 WP_001017131.1 1734614..1735657(+) (vraS) [Staphylococcus aureus strain MRSA - AMRF 5]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=490238 ILP77_RS08545 WP_001017131.1 1734614..1735657(+) (vraS) [Staphylococcus aureus strain MRSA - AMRF 5]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1