Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   ILP78_RS04375 Genome accession   NZ_CP062465
Coordinates   909327..910043 (-) Length   238 a.a.
NCBI ID   WP_000688498.1    Uniprot ID   Q2VG52
Organism   Staphylococcus aureus strain MRSA - AMRF 6     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 904327..915043
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ILP78_RS04355 (ILP78_04355) - 905419..906369 (+) 951 WP_000790325.1 LacI family DNA-binding transcriptional regulator -
  ILP78_RS04360 (ILP78_04360) - 906518..908002 (+) 1485 WP_000141414.1 sucrose-6-phosphate hydrolase -
  ILP78_RS04365 (ILP78_04365) - 907999..908958 (+) 960 WP_001253293.1 carbohydrate kinase family protein -
  ILP78_RS04370 (ILP78_04370) - 909146..909255 (-) 110 Protein_857 hypothetical protein -
  ILP78_RS04375 (ILP78_04375) agrA 909327..910043 (-) 717 WP_000688498.1 quorum-sensing response regulator AgrA Regulator
  ILP78_RS04380 (ILP78_04380) agrC 910062..911354 (-) 1293 WP_194085885.1 quorum-sensing sensor histidine kinase AgrC -
  ILP78_RS04385 (ILP78_04385) agrD 911379..911519 (-) 141 WP_000735197.1 cyclic lactone autoinducer peptide AgrD -
  ILP78_RS04390 (ILP78_04390) - 911523..912086 (-) 564 WP_001105704.1 accessory gene regulator AgrB -
  ILP78_RS14915 hld 912376..912456 (+) 81 WP_000046022.1 delta-hemolysin -
  ILP78_RS04400 (ILP78_04400) - 913056..913841 (-) 786 WP_000867951.1 carbon-nitrogen family hydrolase -
  ILP78_RS04405 (ILP78_04405) - 914202..914828 (-) 627 WP_000522384.1 nitroreductase family protein -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27933.91 Da        Isoelectric Point: 6.0927

>NTDB_id=490188 ILP78_RS04375 WP_000688498.1 909327..910043(-) (agrA) [Staphylococcus aureus strain MRSA - AMRF 6]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSRDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=490188 ILP78_RS04375 WP_000688498.1 909327..910043(-) (agrA) [Staphylococcus aureus strain MRSA - AMRF 6]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGACCCA
GTTGGTAACATTATTTTCGTTACGAGTCACAGTGAACTTACCTATTTAACATTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAAGATGATCCAGCAGAATTAAGAACTCGAATTATAGATTGTTTAGAAACTGCACATACACGTTTACAATTAT
TATCAAGAGATAATAGCGTTGAAACGATTGAATTAAAACGTGGCAGTAATTCAGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACAAAATCTCACAGACTCATTGCCCATTTAGATAACCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGTTTCTTTAGATGTCATAATAGCTTTGTCGTCAATCGCCATAATATTGAATCTATAG
ATTCGAAAGAGCGAATTGTCTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-237)

Response regulator receiver domain (Response_reg)

(3-120)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q2VG52

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

99.58

100

0.996