Detailed information NTG0490016

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF697_RS00505
• Genome accession: NZ_CP062419
• Coordinates: 90960..92003 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_023
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 85960..97003

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF697_RS00475 (IF697_00465)	-	86389..86499 (+)	111	WP_001790257.1	hypothetical protein	-
IF697_RS00480 (IF697_00470)	-	86528..86941 (+)	414	WP_025173836.1	hypothetical protein	-
IF697_RS00485 (IF697_00475)	-	87372..88358 (-)	987	WP_000999714.1	aromatic acid exporter family protein	-
IF697_RS00490 (IF697_00480)	map	88886..89644 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF697_RS00495 (IF697_00485)	-	89861..90247 (+)	387	WP_001110179.1	hypothetical protein	-
IF697_RS00500 (IF697_00490)	liaF	90262..90963 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF697_RS00505 (IF697_00495)	vraS	90960..92003 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF697_RS00510 (IF697_00500)	vraR	91993..92622 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
IF697_RS00515 (IF697_00505)	-	92734..93951 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
IF697_RS00520 (IF697_00510)	-	94229..94504 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF697_RS00525 (IF697_00515)	-	94511..94975 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF697_RS00530 (IF697_00520)	-	95122..95322 (+)	201	WP_000180460.1	DUF1128 family protein	-
IF697_RS00535 (IF697_00525)	-	95325..96581 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=490016 IF697_RS00505 WP_001017131.1 90960..92003(+) (vraS) [Staphylococcus aureus strain NAS_AN_023]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=490016 IF697_RS00505 WP_001017131.1 90960..92003(+) (vraS) [Staphylococcus aureus strain NAS_AN_023]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1