Detailed information NTG0489849

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF720_RS00460
• Genome accession: NZ_CP062415
• Coordinates: 86529..87572 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_150
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 81529..92572

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF720_RS00430 (IF720_00435)	-	81972..82082 (+)	111	WP_001790257.1	hypothetical protein	-
IF720_RS00435 (IF720_00440)	-	82111..82524 (+)	414	WP_001643743.1	hypothetical protein	-
IF720_RS00440 (IF720_00445)	-	82713..83699 (-)	987	WP_001014423.1	aromatic acid exporter family protein	-
IF720_RS00445 (IF720_00450)	map	84455..85213 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF720_RS00450 (IF720_00455)	-	85430..85816 (+)	387	WP_001110178.1	hypothetical protein	-
IF720_RS00455 (IF720_00460)	liaF	85831..86532 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF720_RS00460 (IF720_00465)	vraS	86529..87572 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF720_RS00465 (IF720_00470)	vraR	87562..88191 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
IF720_RS00470 (IF720_00475)	-	88304..89521 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
IF720_RS00475 (IF720_00480)	-	89799..90074 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF720_RS00480 (IF720_00485)	-	90081..90545 (-)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
IF720_RS00485 (IF720_00490)	-	90692..90892 (+)	201	WP_000180460.1	DUF1128 family protein	-
IF720_RS00490 (IF720_00495)	-	90895..92151 (+)	1257	WP_001793983.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=489849 IF720_RS00460 WP_001017131.1 86529..87572(+) (vraS) [Staphylococcus aureus strain NAS_AN_150]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=489849 IF720_RS00460 WP_001017131.1 86529..87572(+) (vraS) [Staphylococcus aureus strain NAS_AN_150]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1