Detailed information NTG0048979

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: STH8232_RS01815
• Genome accession: NC_017581
• Coordinates: 332353..333870 (+)
• Length: 505 a.a.
• NCBI ID: WP_002949640.1
• Uniprot ID: A0A060BQ50
• Organism: Streptococcus thermophilus JIM 8232
• Function: repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 327353..338870

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STH8232_RS11685	-	327633..327803 (+)	171	Protein_299	ascorbate 6-phosphate lactonase	-
STH8232_RS01790 (STH8232_0407)	-	327820..328491 (-)	672	WP_002946492.1	potassium channel family protein	-
STH8232_RS01795 (STH8232_0408)	-	328531..329895 (-)	1365	WP_011680735.1	TrkH family potassium uptake protein	-
STH8232_RS01800 (STH8232_0409)	rsmG	329965..330678 (-)	714	WP_002946490.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
STH8232_RS01805 (STH8232_0410)	-	330975..331511 (+)	537	WP_002946488.1	DUF177 domain-containing protein	-
STH8232_RS01810 (STH8232_0411)	covR	331667..332356 (+)	690	WP_002949638.1	response regulator transcription factor	Regulator
STH8232_RS01815 (STH8232_0412)	covS	332353..333870 (+)	1518	WP_002949640.1	HAMP domain-containing histidine kinase	Regulator
STH8232_RS01820 (STH8232_0413)	nrdR	333992..334471 (+)	480	WP_011680738.1	transcriptional regulator NrdR	-
STH8232_RS01825 (STH8232_0414)	-	334468..335649 (+)	1182	WP_014621158.1	DnaD domain protein	-
STH8232_RS01830 (STH8232_0415)	dnaI	335653..336555 (+)	903	WP_011680740.1	primosomal protein DnaI	-
STH8232_RS01835 (STH8232_0416)	der	336661..337971 (+)	1311	WP_014607972.1	ribosome biogenesis GTPase Der	-
STH8232_RS12195	-	338035..338694 (+)	660	Protein_310	HI_0552 family protein	-

Sequence

Protein

• Length: 505 a.a.
• Molecular weight: 57536.93 Da
• Isoelectric Point: 5.2689

>NTDB_id=48979 STH8232_RS01815 WP_002949640.1 332353..333870(+) (covS) [Streptococcus thermophilus JIM 8232]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSVYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide

• Length: 1518 bp

>NTDB_id=48979 STH8232_RS01815 WP_002949640.1 332353..333870(+) (covS) [Streptococcus thermophilus JIM 8232]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTGTCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (384-494)

• ArlS sensor domain (ArlS_N) (39-187)

• His Kinase A (phospho-acceptor) domain (HisKA) (270-329)

• HAMP domain (HAMP) (213-265)

3D structure

• AlphaFold DB: A0A060BQ50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Streptococcus salivarius strain HSISS4	94.622	99.406	0.941