Detailed information NTG0489765

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF724_RS00790
• Genome accession: NZ_CP062413
• Coordinates: 124668..125711 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_176
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 119668..130711

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF724_RS00760 (IF724_00760)	-	120094..120204 (+)	111	WP_001790257.1	hypothetical protein	-
IF724_RS00765 (IF724_00765)	-	120233..120646 (+)	414	WP_001557448.1	hypothetical protein	-
IF724_RS00770 (IF724_00770)	-	121077..122063 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
IF724_RS00775 (IF724_00775)	map	122594..123352 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF724_RS00780 (IF724_00780)	-	123569..123955 (+)	387	WP_001110179.1	hypothetical protein	-
IF724_RS00785 (IF724_00785)	liaF	123970..124671 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF724_RS00790 (IF724_00790)	vraS	124668..125711 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF724_RS00795 (IF724_00795)	vraR	125701..126330 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
IF724_RS00800 (IF724_00800)	-	126443..127660 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
IF724_RS00805 (IF724_00805)	-	127938..128213 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF724_RS00810 (IF724_00810)	-	128220..128684 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF724_RS00815 (IF724_00815)	-	128831..129031 (+)	201	WP_000180460.1	DUF1128 family protein	-
IF724_RS00820 (IF724_00820)	-	129034..130290 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=489765 IF724_RS00790 WP_001017131.1 124668..125711(+) (vraS) [Staphylococcus aureus strain NAS_AN_176]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=489765 IF724_RS00790 WP_001017131.1 124668..125711(+) (vraS) [Staphylococcus aureus strain NAS_AN_176]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1