Detailed information NTG0489722

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF725_RS00505
• Genome accession: NZ_CP062412
• Coordinates: 91029..92072 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_181
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 86029..97072

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF725_RS00475 (IF725_00460)	-	86458..86568 (+)	111	WP_001790257.1	hypothetical protein	-
IF725_RS00480 (IF725_00465)	-	86597..87010 (+)	414	WP_025173836.1	hypothetical protein	-
IF725_RS00485 (IF725_00470)	-	87441..88427 (-)	987	WP_000999714.1	aromatic acid exporter family protein	-
IF725_RS00490 (IF725_00475)	map	88955..89713 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF725_RS00495 (IF725_00480)	-	89930..90316 (+)	387	WP_001110179.1	hypothetical protein	-
IF725_RS00500 (IF725_00485)	liaF	90331..91032 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF725_RS00505 (IF725_00490)	vraS	91029..92072 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF725_RS00510 (IF725_00495)	vraR	92062..92691 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
IF725_RS00515 (IF725_00500)	-	92803..94020 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
IF725_RS00520 (IF725_00505)	-	94298..94573 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF725_RS00525 (IF725_00510)	-	94580..95044 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF725_RS00530 (IF725_00515)	-	95191..95391 (+)	201	WP_000180460.1	DUF1128 family protein	-
IF725_RS00535 (IF725_00520)	-	95394..96650 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=489722 IF725_RS00505 WP_001017131.1 91029..92072(+) (vraS) [Staphylococcus aureus strain NAS_AN_181]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=489722 IF725_RS00505 WP_001017131.1 91029..92072(+) (vraS) [Staphylococcus aureus strain NAS_AN_181]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1