Detailed information NTG0489548

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF735_RS00500
• Genome accession: NZ_CP062408
• Coordinates: 89062..90105 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_247
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 84062..95105

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF735_RS00470 (IF735_00460)	-	84547..84657 (+)	111	WP_001790257.1	hypothetical protein	-
IF735_RS00475 (IF735_00465)	-	84686..85099 (+)	414	WP_025173836.1	hypothetical protein	-
IF735_RS00480 (IF735_00470)	-	85530..86516 (-)	987	WP_000999714.1	aromatic acid exporter family protein	-
IF735_RS00485 (IF735_00475)	map	86988..87746 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF735_RS00490 (IF735_00480)	-	87963..88349 (+)	387	WP_001110179.1	hypothetical protein	-
IF735_RS00495 (IF735_00485)	liaF	88364..89065 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF735_RS00500 (IF735_00490)	vraS	89062..90105 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF735_RS00505 (IF735_00495)	vraR	90095..90724 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
IF735_RS00510 (IF735_00500)	-	90836..92053 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
IF735_RS00515 (IF735_00505)	-	92331..92606 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF735_RS00520 (IF735_00510)	-	92613..93077 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF735_RS00525 (IF735_00515)	-	93224..93424 (+)	201	WP_000180460.1	DUF1128 family protein	-
IF735_RS00530 (IF735_00520)	-	93427..94683 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=489548 IF735_RS00500 WP_001017131.1 89062..90105(+) (vraS) [Staphylococcus aureus strain NAS_AN_247]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=489548 IF735_RS00500 WP_001017131.1 89062..90105(+) (vraS) [Staphylococcus aureus strain NAS_AN_247]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1