Detailed information NTG0489530

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF751_RS11435
• Genome accession: NZ_CP062407
• Coordinates: 2371003..2372046 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_NP_181
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2366003..2377046

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF751_RS11405 (IF751_11315)	-	2366732..2366842 (+)	111	WP_001790257.1	hypothetical protein	-
IF751_RS11410 (IF751_11320)	-	2366871..2367284 (+)	414	WP_020977397.1	hypothetical protein	-
IF751_RS11415 (IF751_11325)	-	2367473..2368459 (-)	987	WP_000999715.1	aromatic acid exporter family protein	-
IF751_RS11420 (IF751_11330)	map	2368929..2369687 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF751_RS11425 (IF751_11335)	-	2369904..2370290 (+)	387	WP_001110179.1	hypothetical protein	-
IF751_RS11430 (IF751_11340)	liaF	2370305..2371006 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF751_RS11435 (IF751_11345)	vraS	2371003..2372046 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF751_RS11440 (IF751_11350)	vraR	2372036..2372665 (+)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
IF751_RS11445 (IF751_11355)	-	2372778..2373995 (-)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
IF751_RS11450 (IF751_11360)	-	2374273..2374548 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF751_RS11455 (IF751_11365)	-	2374555..2375019 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF751_RS11460 (IF751_11370)	-	2375166..2375366 (+)	201	WP_000180460.1	DUF1128 family protein	-
IF751_RS11465 (IF751_11375)	-	2375369..2376625 (+)	1257	WP_078066285.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=489530 IF751_RS11435 WP_001017131.1 2371003..2372046(+) (vraS) [Staphylococcus aureus strain NAS_NP_181]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=489530 IF751_RS11435 WP_001017131.1 2371003..2372046(+) (vraS) [Staphylococcus aureus strain NAS_NP_181]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1