Detailed information NTG0489456

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF754_RS08650
• Genome accession: NZ_CP062405
• Coordinates: 1703734..1704777 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_NP_209
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1698734..1709777

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF754_RS08620 (IF754_08585)	-	1699155..1700411 (-)	1257	WP_001793983.1	aminopeptidase	-
IF754_RS08625 (IF754_08590)	-	1700414..1700614 (-)	201	WP_000180460.1	DUF1128 family protein	-
IF754_RS08630 (IF754_08595)	-	1700761..1701225 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
IF754_RS08635 (IF754_08600)	-	1701232..1701507 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
IF754_RS08640 (IF754_08605)	-	1701785..1703002 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
IF754_RS08645 (IF754_08610)	vraR	1703115..1703744 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
IF754_RS08650 (IF754_08615)	vraS	1703734..1704777 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF754_RS08655 (IF754_08620)	liaF	1704774..1705475 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF754_RS08660 (IF754_08625)	-	1705490..1705876 (-)	387	WP_001110178.1	hypothetical protein	-
IF754_RS08665 (IF754_08630)	map	1706093..1706851 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF754_RS08670 (IF754_08635)	-	1707551..1708537 (+)	987	WP_001014423.1	aromatic acid exporter family protein	-
IF754_RS08675 (IF754_08640)	-	1708726..1709139 (-)	414	WP_001643743.1	hypothetical protein	-
IF754_RS08680 (IF754_08645)	-	1709168..1709278 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=489456 IF754_RS08650 WP_001017131.1 1703734..1704777(-) (vraS) [Staphylococcus aureus strain NAS_NP_209]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=489456 IF754_RS08650 WP_001017131.1 1703734..1704777(-) (vraS) [Staphylococcus aureus strain NAS_NP_209]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1