Detailed information NTG0489218

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF772_RS00450
• Genome accession: NZ_CP062400
• Coordinates: 82015..83058 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_OP_107
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77015..88058

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF772_RS00420 (IF772_00420)	-	77441..77551 (+)	111	WP_001790257.1	hypothetical protein	-
IF772_RS00425 (IF772_00425)	-	77580..77993 (+)	414	WP_001549145.1	hypothetical protein	-
IF772_RS00430 (IF772_00430)	-	78424..79410 (-)	987	WP_031811349.1	aromatic acid exporter family protein	-
IF772_RS00435 (IF772_00435)	map	79941..80699 (+)	759	WP_000636144.1	type I methionyl aminopeptidase	-
IF772_RS00440 (IF772_00440)	-	80916..81302 (+)	387	WP_001110179.1	hypothetical protein	-
IF772_RS00445 (IF772_00445)	liaF	81317..82018 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF772_RS00450 (IF772_00450)	vraS	82015..83058 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF772_RS00455 (IF772_00455)	vraR	83048..83677 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
IF772_RS00460 (IF772_00460)	-	83789..85006 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
IF772_RS00465 (IF772_00465)	-	85284..85559 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF772_RS00470 (IF772_00470)	-	85566..86030 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF772_RS00475 (IF772_00475)	-	86177..86377 (+)	201	WP_000180463.1	DUF1128 family protein	-
IF772_RS00480 (IF772_00480)	-	86380..87636 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=489218 IF772_RS00450 WP_001017131.1 82015..83058(+) (vraS) [Staphylococcus aureus strain NAS_OP_107]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=489218 IF772_RS00450 WP_001017131.1 82015..83058(+) (vraS) [Staphylococcus aureus strain NAS_OP_107]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1