Detailed information NTG0489211

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF777_RS09865
• Genome accession: NZ_CP062399
• Coordinates: 1996317..1997360 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_OP_143
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1991317..2002360

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF777_RS09835 (IF777_09800)	-	1991739..1992995 (-)	1257	WP_078103502.1	aminopeptidase	-
IF777_RS09840 (IF777_09805)	-	1992998..1993198 (-)	201	WP_000180460.1	DUF1128 family protein	-
IF777_RS09845 (IF777_09810)	-	1993345..1993809 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF777_RS09850 (IF777_09815)	-	1993816..1994091 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
IF777_RS09855 (IF777_09820)	-	1994369..1995586 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
IF777_RS09860 (IF777_09825)	vraR	1995698..1996327 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
IF777_RS09865 (IF777_09830)	vraS	1996317..1997360 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF777_RS09870 (IF777_09835)	liaF	1997357..1998058 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF777_RS09875 (IF777_09840)	-	1998073..1998459 (-)	387	WP_001110179.1	hypothetical protein	-
IF777_RS09880 (IF777_09845)	map	1998676..1999434 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF777_RS09885 (IF777_09850)	-	1999965..2000951 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
IF777_RS09890 (IF777_09855)	-	2001382..2001795 (-)	414	WP_001566709.1	hypothetical protein	-
IF777_RS09895 (IF777_09860)	-	2001824..2001934 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=489211 IF777_RS09865 WP_001017131.1 1996317..1997360(-) (vraS) [Staphylococcus aureus strain NAS_OP_143]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=489211 IF777_RS09865 WP_001017131.1 1996317..1997360(-) (vraS) [Staphylococcus aureus strain NAS_OP_143]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACTCAAATATTTGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1