Detailed information NTG0489169

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF781_RS09435
• Genome accession: NZ_CP062398
• Coordinates: 1917060..1918103 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_OP_154
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1912060..1923103

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF781_RS09405 (IF781_09360)	-	1912481..1913737 (-)	1257	WP_001795108.1	aminopeptidase	-
IF781_RS09410 (IF781_09365)	-	1913740..1913940 (-)	201	WP_000180460.1	DUF1128 family protein	-
IF781_RS09415 (IF781_09370)	-	1914087..1914551 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF781_RS09420 (IF781_09375)	-	1914558..1914833 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
IF781_RS09425 (IF781_09380)	-	1915111..1916328 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
IF781_RS09430 (IF781_09385)	vraR	1916441..1917070 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
IF781_RS09435 (IF781_09390)	vraS	1917060..1918103 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF781_RS09440 (IF781_09395)	liaF	1918100..1918801 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF781_RS09445 (IF781_09400)	-	1918816..1919202 (-)	387	WP_001110179.1	hypothetical protein	-
IF781_RS09450 (IF781_09405)	map	1919419..1920177 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF781_RS09455 (IF781_09410)	-	1920708..1921694 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
IF781_RS09460 (IF781_09415)	-	1922125..1922538 (-)	414	WP_001557448.1	hypothetical protein	-
IF781_RS09465 (IF781_09420)	-	1922567..1922677 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=489169 IF781_RS09435 WP_001017131.1 1917060..1918103(-) (vraS) [Staphylococcus aureus strain NAS_OP_154]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=489169 IF781_RS09435 WP_001017131.1 1917060..1918103(-) (vraS) [Staphylococcus aureus strain NAS_OP_154]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1