Detailed information NTG0489094

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF694_RS00370
• Genome accession: NZ_CP062395
• Coordinates: 68712..69755 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_005
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 63712..74755

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF694_RS00335 (IF694_00330)	-	64214..64324 (+)	111	WP_001790257.1	hypothetical protein	-
IF694_RS00340 (IF694_00335)	-	64353..64766 (+)	414	WP_025174475.1	hypothetical protein	-
IF694_RS00345 (IF694_00340)	-	64955..65941 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
IF694_RS00350 (IF694_00345)	-	66114..66569 (+)	456	WP_141724549.1	hypothetical protein	-
IF694_RS00355 (IF694_00350)	map	66638..67396 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF694_RS00360 (IF694_00355)	-	67613..67999 (+)	387	WP_001110179.1	hypothetical protein	-
IF694_RS00365 (IF694_00360)	liaF	68014..68715 (+)	702	WP_000149068.1	cell wall-active antibiotics response protein LiaF	-
IF694_RS00370 (IF694_00365)	vraS	68712..69755 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF694_RS00375 (IF694_00370)	vraR	69745..70374 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
IF694_RS00380 (IF694_00375)	-	70487..71704 (-)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
IF694_RS00385 (IF694_00380)	-	71982..72257 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF694_RS00390 (IF694_00385)	-	72264..72728 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF694_RS00395 (IF694_00390)	-	72875..73075 (+)	201	WP_000180462.1	DUF1128 family protein	-
IF694_RS00400 (IF694_00395)	-	73078..74334 (+)	1257	WP_078103411.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=489094 IF694_RS00370 WP_001017131.1 68712..69755(+) (vraS) [Staphylococcus aureus strain NAS_AN_005]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=489094 IF694_RS00370 WP_001017131.1 68712..69755(+) (vraS) [Staphylococcus aureus strain NAS_AN_005]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCGGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1