Detailed information NTG0488847

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF703_RS00495
• Genome accession: NZ_CP062382
• Coordinates: 90100..91143 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_068
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 85100..96143

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF703_RS00465 (IF703_00460)	-	85660..85770 (+)	111	WP_001790257.1	hypothetical protein	-
IF703_RS00470 (IF703_00465)	-	85799..86212 (+)	414	WP_025174475.1	hypothetical protein	-
IF703_RS00475 (IF703_00470)	-	86401..87387 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
IF703_RS00480 (IF703_00475)	map	88026..88784 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF703_RS00485 (IF703_00480)	-	89001..89387 (+)	387	WP_001110179.1	hypothetical protein	-
IF703_RS00490 (IF703_00485)	liaF	89402..90103 (+)	702	WP_000149068.1	cell wall-active antibiotics response protein LiaF	-
IF703_RS00495 (IF703_00490)	vraS	90100..91143 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF703_RS00500 (IF703_00495)	vraR	91133..91762 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
IF703_RS00505 (IF703_00500)	-	91875..93092 (-)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
IF703_RS00510 (IF703_00505)	-	93370..93645 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF703_RS00515 (IF703_00510)	-	93652..94116 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF703_RS00520 (IF703_00515)	-	94263..94463 (+)	201	WP_000180462.1	DUF1128 family protein	-
IF703_RS00525 (IF703_00520)	-	94466..95722 (+)	1257	WP_078103411.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=488847 IF703_RS00495 WP_001017131.1 90100..91143(+) (vraS) [Staphylococcus aureus strain NAS_AN_068]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=488847 IF703_RS00495 WP_001017131.1 90100..91143(+) (vraS) [Staphylococcus aureus strain NAS_AN_068]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTGCCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCGGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1