Detailed information NTG0488806

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF704_RS00860
• Genome accession: NZ_CP062380
• Coordinates: 136646..137689 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_076
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 131646..142689

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF704_RS00830 (IF704_00820)	-	132148..132258 (+)	111	WP_001790257.1	hypothetical protein	-
IF704_RS00835 (IF704_00825)	-	132287..132700 (+)	414	WP_025174475.1	hypothetical protein	-
IF704_RS00840 (IF704_00830)	-	132889..133875 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
IF704_RS00845 (IF704_00840)	map	134572..135330 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF704_RS00850 (IF704_00845)	-	135547..135933 (+)	387	WP_001110179.1	hypothetical protein	-
IF704_RS00855 (IF704_00850)	liaF	135948..136649 (+)	702	WP_000149068.1	cell wall-active antibiotics response protein LiaF	-
IF704_RS00860 (IF704_00855)	vraS	136646..137689 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF704_RS00865 (IF704_00860)	vraR	137679..138308 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
IF704_RS00870 (IF704_00865)	-	138421..139638 (-)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
IF704_RS00875 (IF704_00870)	-	139916..140191 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF704_RS00880 (IF704_00875)	-	140198..140662 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF704_RS00885 (IF704_00880)	-	140809..141009 (+)	201	WP_000180462.1	DUF1128 family protein	-
IF704_RS00890 (IF704_00885)	-	141012..142268 (+)	1257	WP_078103411.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=488806 IF704_RS00860 WP_001017131.1 136646..137689(+) (vraS) [Staphylococcus aureus strain NAS_AN_076]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=488806 IF704_RS00860 WP_001017131.1 136646..137689(+) (vraS) [Staphylococcus aureus strain NAS_AN_076]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCGGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1