Detailed information NTG0488596

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF712_RS00455
• Genome accession: NZ_CP062368
• Coordinates: 82927..83970 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_115
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77927..88970

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF712_RS00425 (IF712_00425)	-	78353..78463 (+)	111	WP_001790257.1	hypothetical protein	-
IF712_RS00430 (IF712_00430)	-	78492..78905 (+)	414	WP_001557448.1	hypothetical protein	-
IF712_RS00435 (IF712_00435)	-	79336..80322 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
IF712_RS00440 (IF712_00440)	map	80853..81611 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF712_RS00445 (IF712_00445)	-	81828..82214 (+)	387	WP_001110179.1	hypothetical protein	-
IF712_RS00450 (IF712_00450)	liaF	82229..82930 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF712_RS00455 (IF712_00455)	vraS	82927..83970 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF712_RS00460 (IF712_00460)	vraR	83960..84589 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
IF712_RS00465 (IF712_00465)	-	84702..85919 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
IF712_RS00470 (IF712_00470)	-	86197..86472 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF712_RS00475 (IF712_00475)	-	86479..86943 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF712_RS00480 (IF712_00480)	-	87090..87290 (+)	201	WP_000180460.1	DUF1128 family protein	-
IF712_RS00485 (IF712_00485)	-	87293..88549 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=488596 IF712_RS00455 WP_001017131.1 82927..83970(+) (vraS) [Staphylococcus aureus strain NAS_AN_115]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=488596 IF712_RS00455 WP_001017131.1 82927..83970(+) (vraS) [Staphylococcus aureus strain NAS_AN_115]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1