Detailed information NTG0488554

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF713_RS00455
• Genome accession: NZ_CP062366
• Coordinates: 81968..83011 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_123
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76968..88011

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF713_RS00425 (IF713_00430)	-	77339..77449 (+)	111	WP_001790257.1	hypothetical protein	-
IF713_RS00430 (IF713_00435)	-	77478..77891 (+)	414	WP_001549145.1	hypothetical protein	-
IF713_RS00435 (IF713_00440)	-	78381..79367 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
IF713_RS00440 (IF713_00445)	map	79894..80652 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF713_RS00445 (IF713_00450)	-	80869..81255 (+)	387	WP_001110179.1	hypothetical protein	-
IF713_RS00450 (IF713_00455)	liaF	81270..81971 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF713_RS00455 (IF713_00460)	vraS	81968..83011 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF713_RS00460 (IF713_00465)	vraR	83001..83630 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
IF713_RS00465 (IF713_00470)	-	83746..84963 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
IF713_RS00470 (IF713_00475)	-	85241..85516 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF713_RS00475 (IF713_00480)	-	85523..85987 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF713_RS00480 (IF713_00485)	-	86134..86334 (+)	201	WP_000180461.1	DUF1128 family protein	-
IF713_RS00485 (IF713_00490)	-	86337..87593 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=488554 IF713_RS00455 WP_001017131.1 81968..83011(+) (vraS) [Staphylococcus aureus strain NAS_AN_123]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=488554 IF713_RS00455 WP_001017131.1 81968..83011(+) (vraS) [Staphylococcus aureus strain NAS_AN_123]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1