Detailed information NTG0488471

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF721_RS00505
• Genome accession: NZ_CP062362
• Coordinates: 90963..92006 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_152
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 85963..97006

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF721_RS00475 (IF721_00465)	-	86392..86502 (+)	111	WP_001790257.1	hypothetical protein	-
IF721_RS00480 (IF721_00470)	-	86531..86944 (+)	414	WP_025173836.1	hypothetical protein	-
IF721_RS00485 (IF721_00475)	-	87375..88361 (-)	987	WP_000999714.1	aromatic acid exporter family protein	-
IF721_RS00490 (IF721_00480)	map	88889..89647 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF721_RS00495 (IF721_00485)	-	89864..90250 (+)	387	WP_001110179.1	hypothetical protein	-
IF721_RS00500 (IF721_00490)	liaF	90265..90966 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF721_RS00505 (IF721_00495)	vraS	90963..92006 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF721_RS00510 (IF721_00500)	vraR	91996..92625 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
IF721_RS00515 (IF721_00505)	-	92737..93954 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
IF721_RS00520 (IF721_00510)	-	94232..94507 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF721_RS00525 (IF721_00515)	-	94514..94978 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF721_RS00530 (IF721_00520)	-	95125..95325 (+)	201	WP_000180460.1	DUF1128 family protein	-
IF721_RS00535 (IF721_00525)	-	95328..96584 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=488471 IF721_RS00505 WP_001017131.1 90963..92006(+) (vraS) [Staphylococcus aureus strain NAS_AN_152]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=488471 IF721_RS00505 WP_001017131.1 90963..92006(+) (vraS) [Staphylococcus aureus strain NAS_AN_152]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1