Detailed information NTG0488343

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF727_RS00450
• Genome accession: NZ_CP062356
• Coordinates: 81434..82477 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_203
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76434..87477

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF727_RS00420 (IF727_00420)	-	76860..76970 (+)	111	WP_001790257.1	hypothetical protein	-
IF727_RS00425 (IF727_00425)	-	76999..77412 (+)	414	WP_001557448.1	hypothetical protein	-
IF727_RS00430 (IF727_00430)	-	77843..78829 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
IF727_RS00435 (IF727_00435)	map	79360..80118 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF727_RS00440 (IF727_00440)	-	80335..80721 (+)	387	WP_001110179.1	hypothetical protein	-
IF727_RS00445 (IF727_00445)	liaF	80736..81437 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF727_RS00450 (IF727_00450)	vraS	81434..82477 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF727_RS00455 (IF727_00455)	vraR	82467..83096 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
IF727_RS00460 (IF727_00460)	-	83209..84426 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
IF727_RS00465 (IF727_00465)	-	84704..84979 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF727_RS00470 (IF727_00470)	-	84986..85450 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF727_RS00475 (IF727_00475)	-	85597..85797 (+)	201	WP_000180460.1	DUF1128 family protein	-
IF727_RS00480 (IF727_00480)	-	85800..87056 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=488343 IF727_RS00450 WP_001017131.1 81434..82477(+) (vraS) [Staphylococcus aureus strain NAS_AN_203]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=488343 IF727_RS00450 WP_001017131.1 81434..82477(+) (vraS) [Staphylococcus aureus strain NAS_AN_203]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1