Detailed information NTG0488219

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF736_RS00505
• Genome accession: NZ_CP062350
• Coordinates: 90957..92000 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_250
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 85957..97000

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF736_RS00475 (IF736_00470)	-	86444..86554 (+)	111	WP_001790257.1	hypothetical protein	-
IF736_RS00480 (IF736_00475)	-	86583..86996 (+)	414	WP_001670387.1	hypothetical protein	-
IF736_RS00485 (IF736_00480)	-	87427..88413 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
IF736_RS00490 (IF736_00485)	map	88883..89641 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF736_RS00495 (IF736_00490)	-	89858..90244 (+)	387	WP_001110179.1	hypothetical protein	-
IF736_RS00500 (IF736_00495)	liaF	90259..90960 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF736_RS00505 (IF736_00500)	vraS	90957..92000 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF736_RS00510 (IF736_00505)	vraR	91990..92619 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
IF736_RS00515 (IF736_00510)	-	92731..93948 (-)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
IF736_RS00520 (IF736_00515)	-	94226..94501 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF736_RS00525 (IF736_00520)	-	94508..94972 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF736_RS00530 (IF736_00525)	-	95119..95319 (+)	201	WP_000180460.1	DUF1128 family protein	-
IF736_RS00535 (IF736_00530)	-	95322..96578 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=488219 IF736_RS00505 WP_001017131.1 90957..92000(+) (vraS) [Staphylococcus aureus strain NAS_AN_250]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=488219 IF736_RS00505 WP_001017131.1 90957..92000(+) (vraS) [Staphylococcus aureus strain NAS_AN_250]
ATGAACCACTATATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1