Detailed information NTG0488207

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF738_RS08520
• Genome accession: NZ_CP062348
• Coordinates: 1691478..1692521 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_260
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1686478..1697521

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF738_RS08490 (IF738_08465)	-	1686906..1688162 (-)	1257	WP_001793428.1	aminopeptidase	-
IF738_RS08495 (IF738_08470)	-	1688165..1688365 (-)	201	WP_000180460.1	DUF1128 family protein	-
IF738_RS08500 (IF738_08475)	-	1688512..1688976 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF738_RS08505 (IF738_08480)	-	1688983..1689258 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
IF738_RS08510 (IF738_08485)	-	1689536..1690747 (+)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
IF738_RS08515 (IF738_08490)	vraR	1690859..1691488 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
IF738_RS08520 (IF738_08495)	vraS	1691478..1692521 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF738_RS08525 (IF738_08500)	liaF	1692518..1693219 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF738_RS08530 (IF738_08505)	-	1693234..1693620 (-)	387	WP_001110179.1	hypothetical protein	-
IF738_RS08535 (IF738_08510)	map	1693837..1694595 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF738_RS08540 (IF738_08515)	-	1695126..1696112 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
IF738_RS08545 (IF738_08520)	-	1696602..1697015 (-)	414	WP_001837236.1	hypothetical protein	-
IF738_RS08550 (IF738_08525)	-	1697044..1697155 (-)	112	Protein_1646	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=488207 IF738_RS08520 WP_001017131.1 1691478..1692521(-) (vraS) [Staphylococcus aureus strain NAS_AN_260]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=488207 IF738_RS08520 WP_001017131.1 1691478..1692521(-) (vraS) [Staphylococcus aureus strain NAS_AN_260]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1