Detailed information NTG0488013

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF742_RS00460
• Genome accession: NZ_CP062340
• Coordinates: 83024..84067 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_275
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 78024..89067

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF742_RS00430 (IF742_00425)	-	78390..78501 (+)	112	Protein_86	hypothetical protein	-
IF742_RS00435 (IF742_00430)	-	78530..78943 (+)	414	WP_001566709.1	hypothetical protein	-
IF742_RS00440 (IF742_00435)	-	79374..80360 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
IF742_RS00445 (IF742_00440)	map	80950..81708 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF742_RS00450 (IF742_00445)	-	81925..82311 (+)	387	WP_001110179.1	hypothetical protein	-
IF742_RS00455 (IF742_00450)	liaF	82326..83027 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF742_RS00460 (IF742_00455)	vraS	83024..84067 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF742_RS00465 (IF742_00460)	vraR	84057..84686 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
IF742_RS00470 (IF742_00465)	-	84798..86015 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
IF742_RS00475 (IF742_00470)	-	86293..86568 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF742_RS00480 (IF742_00475)	-	86575..87039 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF742_RS00485 (IF742_00480)	-	87186..87386 (+)	201	WP_000180460.1	DUF1128 family protein	-
IF742_RS00490 (IF742_00485)	-	87389..88645 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=488013 IF742_RS00460 WP_001017131.1 83024..84067(+) (vraS) [Staphylococcus aureus strain NAS_AN_275]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=488013 IF742_RS00460 WP_001017131.1 83024..84067(+) (vraS) [Staphylococcus aureus strain NAS_AN_275]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1